Ilias Iakovidis, PhD

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Biomedical informatics in support of genomic
medicine
Workshop on Biomedical Informatics Brussels
18 March 2004

• Ilias Iakovidis, PhD
• Deputy Head of Unit
• Unit ICT for Health
• Directorate Components and subsystems.
  Applications
• Directorate General Information Society

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20 Years of eHealth in European Union
NEXT 10 years (2003-2014)
PAST 10 years (1991-2002)
Computer Applications for Doctors Telemedicine
systems and services
Regional Health Info Networks Home-care
systems Personal Health Systems
_at_
Budget20M
Budget100M
Budget140M
Budget200M
Projects30
Projects63
Projects158
Projects125
ResultsFeasibility Study
ResultsAIM Community
Results1st batch of Products
ResultsEU Health Telematics Industry
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Biomedical InformaticsKnowledge Empowering
Individual Health Care Well-Being
2.Bioinformatics/Genomics (BI)molecular and cell
informatics
1.Medical Informatics (MI)citizen, patient and
population informatics
Medical Sciences
Biological Sciences

• Electronic Health Records
• Decision Support Systems
• Terminologies, ontologies
• Telemedicine
• Interoperability of systems

• Structural Genomics
• Functional Genomics
• Proteomics
• Biochip Technologies
• Computational Biology

A
D
Example Advancing into the molecular causes of
diseases Genomic Medicine
C
B
Example Informatics in support of the next
generation of brain research Molecular
Neuroscience

• Biosignal Analysis and Pattern Recognition
• Neuro Algorithms
• Neurocell Technology
• Human Computer Interfaces
• Machine Learning

Example integration of genomic and neuroscience
databases Neurogenomics
Behavioral Sciences Social Sciences
3.Neuroinformatics (NI)cell to organ informatics
DG INFSO.B.1/JCH/CVD/ 14.XII.2001/ rings
v19/10/2001
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Examples

• Phenotype is the "outward, physical
  manifestation" of the organism.
• Genotype is the "internally coded, inheritable
  information
• Proteotype total of genes expressed in a cell,
  tissue or organism
• Providing an association between phenotype and
  genotype and proteotype is critical to being able
  to understand and create models of disease. This
  association is also key to targeting critical
  pathways in disease and identifying the genes and
  proteins that regulate biological processes, thus
  identifying better drug targets
• RD topics
• in silico methods for description of cellular
  systems
• Biobanks for validation of biological research
  epidemiology
• Molecular and functional imaging
• New developments in DNA/protein detection will
  pose new challenges for data processing, storage,
  communication and security ( new approach to EHR)
• - HealthGrid

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Synergy between Research inMedical Informatics,
Bio-Informatics and Neuro-Informatics
Knowledge empoweringIndividualised Healthcare
and Well-Being
14 December 2001Pyramids, Place Rogier, Brussels
European Commission DG-Information Society,
DG Research
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BIOINFOMED

• Prospective Analysis on the Relationships and
  Synergy between Medical Informatics and
  Bioinformatics
• URL http//bioinfomed.isciii.es
• Institute of Health Carlos III Madrid (Dr.
  Fernando Martin-Sanchez)
• Polytechnical University of Madrid (Prof. Victor
  Maojo)
• Linkoping University (Prof. Ankica Babic)
• Study brought together 32 experts from Europe and
  US
• Result a research roadmap for BMI

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Biomedical Informatics Synergy between Medical
Informatics, Bioinformatics and
Neuroinformatics Example of synergy between
medical informatics and Bioinformatics
Dr. Fernando Martin-Sanchez
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Biomedical Informaticssynthesizes knowledge at
all levels
Population
Public Health Informatics
Patient
Medical Informatics
Tissue, organ
Medical Imaging
Cell
Molecule, gene
Bioinformatics
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Vision
Computing Grid For data crunching applications

• An environment, created through the sharing of
  resources, in which heterogeneous and dispersed
  health data
• molecular data (ex. genomics, proteomics)
• cellular data (ex. pathways)
• tissue data (ex. cancer types, wound healing)
• personal data (ex. EHR)
• population ( ex. epidemiology)
• as well as applications, can be accessed by all
  users as an tailored information providing system
  according to their authorisation

Knowledge Grid Intelligent use of Data Grid for
knowledge creation and tools provisions to all
users
Data Grid Distributed and optimized storage of
large amounts of accessible data
ICT for Health, ISTAG WG, March 2004
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Objectives of the workshop

• Presentation of all EU funded projects on BMI
• Exchange of information, human networking
• Facilitating the creation of BMI community
• Developing activities stimulating the creation of
  ERA in BMI such as conferences, working groups,
  associations etc
• Identification of areas of synergy
• For example, common approach to dissemination,
  exploitation, maximising industrial validation
  and impact
• Promoting international cooperation and synergy
  with other national and international initiatives
• mutually beneficial international collaboration
  is encouraged, in particular with US, Canada,
  Australia
• Identifying future RD requirements and specific
  topic with short term potential impact
• input to EC work programme 2005 -2006 and FP7

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Preparation of WP 2005 - 2006

• collection of ideas at workshop such as this one
• opening of web based consultation on RD
  requirements
• http//ist.eurodyn.com/fp6_2/top-level/01/workprog
  ramme/wp0506-consultation.htm
• consolidation during the workshop 2-3 June,
  2004, Brussels on Risk Mangement in Healthcare,
  Brussels
• drafting of the Work programme
• European Commission by mid July, previous work
  programme as a basis
• adoption and announcement of Call 4
• (old) Commission by end of October and
  publication mid December

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Conclusions

• Following the successful RD on ICT technologies
  during the last 20 years and the genomics and
  post genomics program during the last 10 years
• the future is bright for interdisciplinary
  research and synthesis of knowledge for health
  combining medical informatics, bioinformatics,
  neuroinformatics (biomedical informatics)
• Expectation from the new projects in the area of
  biomedical informatics to demonstrate the
  potential of the area
• Hope that the workshop can facilitate future
  creation of e an BMI community that will soon
  have an impact on ERA with new knowledge for
  health and new tools and services for health care