JAMs

1
Perivascular Basement Membrane
ß1/ß2 integrins
proteases
IgS EC adhesion molecules
PECAM
CD99
JAMs
PAF chemokines
selectins/ integrins
integrins
ICAM-1/2
ß2 integrins
Shear
Firm adhesion ?1 and ?2 integrins ICAM-1/2 and
VCAM-1
Rolling P-selectin, E-selectin, L-selectin Glycosy
lated ligands VLA-4/VCAM-1
Transmigration PECAM-1 CD99 ICAM-2 JAMs
2

• Figure legend Schematic diagram showing the
  sequential steps involved in leukocyte
  transmigration through stimulated vessel walls,
  indicating the key molecules involved and some
  potential transmigration-induced changes in the
  phenotype of the emigrating leukocytes.
• For details see Yadav et al., Thrombosis and
  Haemostasis, 90 598-606, 2003