Trinucleotide repeats included among microsatellites we studied

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Trinucleotide repeats (included among
microsatellites we studied earlier) are
sometimes genetically unstable in a
characteristic and interesting way they expand
in copy number. Sometimes this expansion can
interfere with the normal function of a
particular gene, causing a trinucleotide repeat
disease. Trinucleotide repeat diseases sometimes
show a phenomenon called genetic anticipation.
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Some basic concepts and vocabulary of gene
regulation 1. Gene action (prok.)
transcription and translation of one or more
specific genes. (euk.) Generally refers to
transcription only. 2. Constitutive genes
gene action at approx. the same level,
regardless of environmental or physiological
changes. Example housekeeping genes. 3.
Inducible genes gene action increases in
response to an increase in concentration of a
substrate, metabolite, etc.). The
latter is called the inducer. 4. Repressible
genes gene action decreases in response to an
increase in concentration of a
substrate, metabolite, etc.). The
latter is called the repressor.
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An operon is a group of closely linked,
functionally related genes, under coordinate
regulation and generally sharing a common
promoter. Usually, operons are transcribed as a
single polycistronic message.
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Isopropyl beta thio-d-galactoside, a gratuitous
inducer.
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