Receptors

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Receptors Plasticity
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2 Categories of Receptors

• Ionotropic
• Contain ion channels
• Fast (1-3mS)
• Closed at rest
• Metabotropic
• Not linked to ion channel
• Slow but actions last much longer
• Engage metabolism of most synaptic cell
• Use 2nd messenger

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Second messengers

• 3 functions
• Bring extracellular signal into cell
• Amplify signal
• Regulate many cell functions in response to signal

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Santiago Ramon y Cajal

• Neuroanatomist
• Neurons connect w/ precise patterns which is
  built in the brain
• WHEN WE LEARN WHAT CHANGES?

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Synaptic Plasticity Hypothesis

• Strength of connections is modifiable by activity
• Learning produces changes in patterns
  intensities of neural signals
• Persistence of changes memory

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Major Neurotransmitter Systems
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