MPOcatalyzed oxidation of HDL impacts on atheroprotective functions:

1
MPO-catalyzed oxidation of HDL impacts on
atheroprotective functions

• Loss of reverse cholesterol transport related
  activities of cholesterol efflux
• Loss of anti-apoptotic activity
• Loss of anti-inflammatory AND gain of
  pro-inflammatory activity
• These data reinforce the concept that both HDL
  quality and quantity are important for
  atheroprotective functions.
• Undurti A et al. J Biol Chem. published on-line
  Sept 2009