Aucun titre de diapositive

1
RanGAP1 fails to be Targeted to the Nuclear Pore
Complex in Ubc9-Deficient Cells
ICM RanGAP1
ICM DAPI
TGC RanGAP1
TGC DAPI
Ubc9/
Ubc9-/-
ICM inner cell mass cells TGC trophoblastic
giant cells
2
SUMO Modification is Necessary for Proper PML
Nuclear Body Formation
Ubc9/ Cells
Ubc9-/- Cells
DAPI / PML
DAPI / PML
3
Lack of Sumoylation Leads to Nuclear Dysmorphy
Ubc9 / cells
Ubc9-/- cells
Antibody
Merge
Antibody
Merge
Lamin B1
4
Loss of Sumoylation Leads to Chromosome
Condensation and Segregation Defects
Ubc9 / Cells
Ubc9 -/- Cells
Metaphase
Metaphase
Anaphase
Anaphase