Nanostructured Scaffolds for Tissue Engineering Applications

1
Nanostructured Scaffolds for Tissue Engineering
Applications

• Nathaniel Hogrebe
• Xia Lab
• Washington University in St. Louis

2
Tendon to Bone Attachment
www.eorthopod.com
3
Bone and Tendon Anatomy
4
Project Goal
5
Scaffolds
www.rsc.org
www.ptei.org
6
Electrospinning
Process by which a solution is made into fibers
through the utilization of an electric current
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Nanofiber Scaffolds
10 µm
Aligned Random
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Biomineralization
9
Mineral Gradients
50 µm
Decreasing Mineral Concentration
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Cell Density
100 µm
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Cell Density
Decreasing Mineral Concentration
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Cell Differentiation
Increasing Mineral Concentration
100 µm
13
Conclusion
www.bocaorthoandsports.com
14
Acknowledgements

• National Nanotechnology Infrastructure Network
  Research Experience for Undergraduates Program
• Dr. Jingwei Xie, Mentor
• Dr. Younan Xia, Principle Investigator
• Xia Lab, Washington University in St. Louis
• Nano Research Facility, Washington University in
  St. Louis

15
References

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