October 24 - 25 , 2005:Can Metabolomics Provide Clues about the Progression of Disease, John Milner, PhD

1
Unprecedented opportunities exist for the
expanded use of foods components to achieve
genetic potential, increase productivity and
reduce the risk of disease.
2
The Omics of Nutrition
Nutrigenomics
DNA
Nutrigenetics
Nutritional Epigenetics
RNA
Nutritional Transcriptomics
Bioactive Food Component
Phenotype
Protein
Proteomics
Metabolomics
Metabolite
3
Nutritional Metabolomics
Nutrigenomics
DNA
Nutrigenetics
Nutritional Epigenetics
Metabolomics
RNA
Nutritional Transcriptomics
Bioactive Food Component
Metabolite
Protein
Proteomics
Phenotype
4
Toxicity
Typical Intakes
Cell Cycle Inhibition Apoptosis
Response
Immune Enhancement
Anti- oxidant
Carcinogen Metabolism
Nutritional
Toxic
Supranutritional
Exposure
Modified from Combs and Gray, Parmacol. Ther. 79
179-192, 1998.
5
Can Metabolomics Shed Light on these 3 Nutrition
Related Biomarkers
Inactive Metabolite
Absorbed Dose
Biologically Effective Dose
Intake of Dietary Constituent
Early Biologic Effect
Susceptibility (Genetic/ Environment)
Altered
Altered
Health Effects and -
Structure
Structure/
Function
Function
6
Can Metabolomics Provide Clues about the
Progression of Disease
Natural History of Disease
Treatment History
Quality Of Life
Outcomes
Environment Lifestyle
Treatment Options
Disease Staging
Patient Stratification
Early Detection
Biomarkers
Genetic Risk