Loukianos Gatzoulis

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ICT WP 2007-08Challenge 5-Strategic
Objective Personal Health Systems for
Monitoring and Point of Care diagnostics

• Loukianos Gatzoulis
• ICT for Health
• DG Information Society Media
• European Commission

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Personal Health Systems - PHS

• A relatively recent concept
• Introduced in the 1990s
• Place the individual citizen in the centre of the
  healthcare delivery process
• Key facilitators for
• Continuity of care
• Preventive personalised care
• Citizen-centred care
• citizen empowerment
• preventive lifestyle early diagnosis
• disease management
• independent living for ageing society

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Personal Health Systems

• Benefits for all
• Health conscious who wish to stay fit
• Healthy individuals at risk who wish to maintain
  normal health status
• Chronically ill patients
• Elderly persons or people in need, who want to
  live independently outside care institutions
• Improving the quality of care
• provision of personalised care (according to the
  detected individual circumstances of a patient)
• Containing the rising healthcare costs
• through proper efficient use of technological
  capabilities

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Personal Health Systems

• In the form of
• Wearable, implantable, portable systems
• Point-of-care systems
• Non-/minimally-invasive monitoring
• Remote and continuous health status monitoring
• Personalised medical advice, recommendations and
  treatment as necessary
• Emphasis so far
• Physiological monitoring (vital signs)
• Physical activity monitoring (body-kinematics)
• Functional stimulation (post-event
  rehabilitation)
• Molecular diagnostics for screening applications
  (e.g. cancer)

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Personal Health Systems

• Examples of FP6 projects
• MYHEART (http//www.hitechprojects.com/euprojects/
  myheart/)
• Wearable systems (intelligent textiles) for
  prevention, early diagnosis and management of
  cardiovascular diseases
• OFSETH (www.ofseth.org)
• Textiles with optical sensors for physiological
  monitoring
• HEARTFAID (www.heartfaid.org)
• Knowledge-based platform for heart failure
  management
• SMARTHEALTH (www.smarthealthip.com) and
• MICROACTIVE (www.sintef.no/microactive)
• Point of care devices for cancer screening
  (breast, cervical and colorectal cancer)

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Prototype PHS for monitoring

• Examples
• Wrist-worn devices
• Body Sensor Networks
• Biomedical clothes

AMON
MOBIHEALTH
MYHEART
WEALTHY
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PHS molecular diagnostics

• Prevention/early identification of a disease
• Lab-on-Chip, microfluidics, integrated sensors
• Integration of different functions in miniature
  devices (preparation, mixing, analysis, etc.)
• Parallel measurements from small samples
• High throughput screening
• Identify predisposition to diseases

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Personal Health Systems Trends and Directions

• Multi-parameter preventive monitoring
• Physiological monitoring (e.g. vital signs)
• Monitoring of biochemical variables
• Non-invasive multi-parameter analysis
• Body fluid analytes (e.g., glucose, lactate,
  other proteins)
• Enable more thorough assessment of a persons
  health status, (e.g. mental health, immune
  system)
• Non-invasive (transdermal) biosensors, even in
  clothes
• Activity and location
• Environmental and social context
• Multi-analyte molecular diagnostics

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Personal Health Systems Challenges

• Multidisciplinary research
• Integrating a number of components and
  technologies
• sensors (non-contact, biochemical, molecular,
  cellular)
• low power control and processing units
• communications (fixed, wireless, mobile networks)
• services over converged platforms
• interfaces
• intelligent SW
• Opportunities from convergence of
• ICT-Bio-Nano- technologies

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FP7 Objective 3.5.1.1 Personal Health Systems
for Monitoring and Point of Care diagnostics

• Focus on
• (a) Personalised (health status) monitoring
• For people at risk or chronically ill
• Wearable or portable/mobile ICT systems
• Enable remote monitoring care
• Multi-parametric information (physiological
  biochemical activity, location, social and
  environmental context)
• Intelligent systems to correlate multi-parametric
  data with expert biomedical knowledge
• aid diagnosis
• user support
• Interoperable with electronic medical records

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FP7 Objective 3.5.1.1 Personal Health Systems
for Monitoring and Point of Care diagnostics

• Focus on
• a1) Chronic disease management
• intelligent closed-loop approaches
• detect and assess trends and episodes
• facilitate adaptive care
• remote management, avoiding hospitalisation
• promote doctor-patient interaction
• potential for integration in the healthcare
  process
• a2) Preventive monitoring for people at risk
• identify evolving patterns/trends in health
  lifestyle parameters
• indicate elevated risks of disease development
• reveal episodes at early stages
• facilitate personalised guidance
• encourage citizen compliance
• prompt for early medical intervention

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FP7 Objective 3.5.1.1 Personal Health Systems
for Monitoring and Point of Care diagnostics

• Focus on
• (b) Point-of-Care diagnostics
• Multi-analyte screening at primary care (GP
  offices)
• Portable or handheld devices (based on LoC,
  microarrays, etc.)
• Multiple tests (e.g. genome, proteome, metabolome
  levels)
• Identify disease predisposition
• Early diagnosis of diseases their recurrence
• Assistance to treatment
• dosage advice
• suitability of drug use
• Significant advances in
• sensitivity and specificity
• data processing, analysis and quality control
• Interface with hospital and laboratory
  information systems electronic medical records

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Additional Aims

• Integrated, holistic approach addressing
• Technological development, but also
• User needs
• Personal data security, confidentiality, privacy
• Reimbursement
• Legal framework
• Validation
• quantitative indicators of added value and
  potential impact
• Integration in healthcare processes
• interoperability with eHealth systems
• favourable conditions for new delivery models

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FP7 Objective 3.5.1.1 Personal Health Systems
for Monitoring and Point of Care diagnostics

• (c) Additional Support Actions on
• RD roadmap on Personal Health Systems
• emerging technologies and potential applications
• user demand and business aspects
• ethical and legal considerations
• Wireless transmission of health-related
  information
• reliability aspects
• need for exclusive radio frequency bands?
• Interoperability of Personal Health Systems with
  other eHealth systems
• promotion and recommendations for continuous care

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FP7 Objective 3.5.1.1 Personal Health Systems
for Monitoring and Point of Care diagnostics

• Expected Impact
• Higher quality care at the patient location
• Better support and reassurance to people at risk
• Stabilise the cost of health delivery systems
• Reinforce leadership of the EU Personal Health
  Systems industry

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FP7 Objective 3.5.1.1 Personal Health Systems
for Monitoring and Point of Care diagnostics

• When Call 1
• Budget 72 M
• Instruments
• (a) Personalised Monitoring IPs
• (b) Point of Care diagnostics IPs
• 70.5 M for (a) and (b)
• (c) Coordination and Support Actions CSAs
• 1.5 M max for (c) 3 x 0.5 M max per topic

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Consultation information

• Personal Health Systems for Monitoring and
  Point-of-Care diagnostics
• Consultation workshop on Personal Health
  Systems the path from FP6 to FP7, Luzern, 2nd
  February 2006. Report available at
  http//europa.eu.int/information_society/activitie
  s/health/docs/events/phealth2006/fp7phs_consultati
  on_workshop_final-report.pdf
• pHealth 2006, International workshop on wearable
  micro- and nanosystems for personalised health,
  Luzern, Switzerland, January 2006
  (http//www.phealth-2006.com)

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Important Event !

• Personal Health Systems Research and Deployment
  Opportunities
• 12-13 February 2007, Brussels
• http//europa.eu.int/information_society/events/ph
  s_2007

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Contact persons

• DG INFSO Unit H1 ICT for Health
• Personal Health Systems for Monitoring and
  Point-of-Care diagnostics
• Rainer Guenzler - Loukianos Gatzoulis
• Emails firstname.surname_at_ec.europa.eu