Institutional Animal Care and Use Committee IACUC

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Institutional Animal Care and Use Committee
(IACUC)
The IACUC provides internal oversight of
animal - husbandry - facilities - use in
teaching research
The ASU IACUC consists of 11 voting members plus
other supporting participants who include -
faculty representing the various departments and
uses of animals - representatives of
relevant ASU service departments - DACT
(including the Attending Veterinarian) -
EHS - Campus Health - VPREA Office -
Risk Management - non-affiliated member
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Institutional Animal Care and Use Committee
(IACUC)

• Web site includes
• Policy and Procedure Manual
• forms
• training instructions and exams
• Occupational Health Safety Program documents
• Standard Institutional Guidelines
• protocol due dates meeting dates
• Animal Welfare Assurance USDA certificate
  numbers
• society non-traditional species guidelines
• AVMA euthanasia guidelines
• federal regulations
• etc.

http//researchintegrity.asu.edu/
animals
iacuc
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Institutional Animal Care and Use Committee
(IACUC)

• Last years 2 aims as the new Chair
• To assure that ASU meets all regulatory
  requirements
• - USDA enforces the Animal Welfare Act.
  Definition of animal?
• - OLAW (Office of Laboratory Animal Welfare)
  oversees the use of non-human vertebrates in
  PHS-supported research (PHS Policy on Humane Care
  and Use of Laboratory Animals, 2002)
• - AAALACi (Association for the Assessment
  Accreditation of Laboratory Animal Care
  International) voluntary, covers all non-human
  vertebrates at the institution
• - U.S. Fish Wildlife Service oversees
  federally protected species and international
  transport of all vertebrate animals and their
  parts
• - Arizona Game Fish Department oversees the
  capture holding of native wildlife, as well as
  the holding of restricted non-native wildlife
• - Arizona Department of Health Services covers
  species where there is a concern for zoonotic
  disease

All mammals except laboratory mice rats
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Institutional Animal Care and Use Committee
(IACUC)

• Last years 2 aims as the new Chair
• To minimize the burden on investigators (provided
  it does not interfere with Aim 1)
• - Require IACUC training and certification
  specific to the investigator, not the protocol.
• - Eliminate the need for duplicative protocols
  in situations where a PI conducts work at
  multiple local institutions.
• - ??

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Institutional Animal Care and Use Committee
(IACUC)

• The review process (details in the Policy
  Procedure Manual)
• Protocols
• - pre-reviewed by the Attending Veterinarian,
  then one other IACUC member (assigned by the
  Chair as the Primary Reviewer)
• - reviewed by the full committee at a convened
  meeting in the presence of the PI or designee
• Amendments
• - Minor administratively approved by the Chair
• - Significant with the approval of the full
  committee, reviewed by a Designated Reviewer
  (assigned by the Chair) and the Attending
  Veterinarian
• - Major reviewed by full committee at a
  convened meeting

- a change that does not in any way effect the
animals

• the rationale for the new procedure is consistent
  with the research goals in the approved protocol
• involves no increased risk of pain, distress, or
  discomfort to animals
• does not markedly increase, by absolute or
  relative terms, the number of animals involved in
  the project

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Changes to the Protocol Form
Why were there changes?

• - section for Additional Contact information
• - split the literature search into two
  separate searches
• - duplicative research
• - alternatives to animal use and painful
  procedures
• includes section to summarize results
• pay close attention to the search words used
• - method of animal identification, if any
• Regulatory oversight is very dynamic, expect more
  changes!
• - qualifications and training of all
  participants
• (in protocols and added in an amendment)

MAKE SURE TO USE THE MOST CURRENT FORM!
(available on the web site)
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