Title: The Biomedical Translational Research Information System BTRIS
1The Biomedical Translational Research Information
System (BTRIS)
- James J. Cimino
- Chief, Laboratory for Informatics Development
- National Institutes of Health Clinical Center
- Senior Scientist, Lister Hill Center for
Biomedical Communications - National Library of Medicine
- Adjunct Professor, Department of Biomedical
Informatics - Columbia University College of Physicians and
Surgeons - September 12, 2008
2Learning Objectives
- An introduction to the compilation and
integration of clinical and research data from
multiple disparate sources - Understanding the authorization issues related to
reuse of patient clinical data - Understanding the terminology issues related to
the reuse of coded clinical and research data - Familiarity with the approach being taken at the
National Institutes of Health to collect,
integrate, and code clinical and research data
into a single repository, for authorized resuse
in biomedical research.
3No Relevant Financial Relationships with
Commercial Interests
Disclosures
4The Clinical Center, 1981
5What Was the Problem?
- Patients in the NIH Clinical Center were on
research protocols, but - their data were in a clinical information system
- Needed to extract individual data for analysis
- Needed cross-patient queries for additional
analysis
6Patient Information Graphics System (PIGS)
- Integration of a desktop computer (pre-PC) to
mainframe clinical information system (TDS) - Download vital sign and drug administration data
- Various graphical displays
- SCAMC, 1981
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10The Columbia University Medical Center Clinical
Data Warehouse
- Clinical data repository to collect data from
ancillary systems - Coded with the Medical Entities Dictionary
11MED Structure
Medical Entity
CHEM-7
Plasma Glucose Test
12Using the MED for Summary Reporting
Lab Display
Serum Glucose Test
Fingerstick Glucose Test
Plasma Glucose Test
13The Columbia University Medical Center Clinical
Data Warehouse
- Clinical data repository to collect data from
ancillary systems - Coded with the Medical Entities Dictionary
- Back end for clinical information systems (CIS,
WebCIS, PatCIS, PalmCIS, QingCIS, MendonÇIS) - Reorganized for use as Clinical Data Warehouse
14How often are patient with the diagnosis of
myocardial infarction started on beta blockers?
15How often are patient with the diagnosis of
myocardial infarction started on beta blockers?
Find all patients with Diagnosis in class
MYOCARDIAL INFARCTION
Find all patients with Diagnosis in class
MYOCARDIAL INFARCTION AND with Medication in
class BETA BLOCKER
16The Clinical Center, 2008
17The Clinical Center, 2008
- Patient data stored in EHR (Eclipsys)
- Need to extract individual data for analysis
- Need cross-patient queries for additional
analysis - Data may require transformation
- De-identification and Re-identification
- Indexing
- Aggregation by time
- Abstraction by classification
- Conversion to relevant concepts
18What is BTRIS?
- Biomedical data
- Research data collected using clinical
information systems - Clinical data collected using clinical
information systems - Research data from research information systems
- Non-human data
- Reuse of data to support translational research
- Hence Biomedical Translational Research
Information System
19The NIH, 2008
20What is BTRIS?
BTRIS
21What is BTRIS?
BTRIS
22What is BTRIS?
O n t o l o g
y
Data Retrieval Functions Authorization
Subject-Oriented Cross-Subject
Re-Identification NLP
Data Repository
BTRIS
23BTRIS Issues
- Data sources
- Data model integration
- Research Entities Dictionary
- Access policies
- User requirements
- User access and user Interface
- Terminology-based queries
24Data Sources
- Order entry system
- Ancillary systems
- Institute and Center (IC) systems
- Individual researchers systems
- Notebooks
25Data Model Integration
- Events and details
- Entity-relation vs entity-attribute-value
- Denormalization
26Research Entities Dictionary
- Apelons Terminology Development Editor
- NCI/caBIG Thesaurus
27Research Entities Dictionary (RED)
28Research Entities Dictionary
- Apelons Terminology Development Editor
- NCI/caBIG Thesaurus
29Access Policies
- Privacy Act, not HIPAA
- Policy Working Group
- Intellectual property vs. public domain
- Identifiers
- Unlinked, coded data
30BTRIS Data Storage Policy
1. All clinical and research data, whether from
active or inactive protocols, are stored in BTRIS
in a timely manner.
31BTRIS Data Use Policy
Active Protocols
Inactive Protocols
2. PIs can see data collected on their patients
as part of their active protocols
32BTRIS Data Use Policy
Blocked By PI
Active Protocols
Inactive Protocols
3. PIs may indicate that some of their data
should be blocked to avoid unmasking their study
subject assignment.
33BTRIS Data Use Policy
Identifiers
Coded Data
Blocked By PI
Active Protocols
Inactive Protocols
4. It is helpful to consider data to consist of
identifiers vs. other (coded) data linked to
those identifiers. PIs can get to coded data in
their own active protocols, but not those in
inactive protocols.
34BTRIS Data Use Policy
Coded Events
Identifiers
Coded Results
Active Protocols
Inactive Protocols
5. It is also helpful to consider that coded data
can be further divided into recorded events (such
as a medication order or a lab result report) and
results (such as the medication ordered or the
value of the test result).
35BTRIS Data Use Policy
Coded Events
Identifiers
Coded Results
Restricted By PI
PI Only
Active Protocols
Sharable Through PI
PI Only
Inactive Protocols
6. Identifiers in active protocols are restricted
to PIs but other data are generally be sharable
with some PI control.
The PI may designate some
events, and perhaps their data, as completely
restricted while the protocol is active.
36BTRIS Data Use Policy
Coded Events
Identifiers
Coded Results
Restricted By PI
PI Only
Active Protocols
Sharable Through PI
PI Only
Unencumbered By PI
No Access
Inactive Protocols
7. When a protocol becomes inactive, the
identifying information is inaccessible, but the
other (coded) data (events and results) become
generally available.
37BTRIS Data Use Policy
Coded Events
Identifiers
Coded Results
Restricted By PI
PI Only
Active Protocols
Sharable Through PI
PI Only
Unencumbered By PI
No Access
Inactive Protocols
Collaborative with PI
8. A PI may restrict use of some data from
inactive protocols, for example requiring other
users of the data to work in collaboration with
the PI.
38BTRIS Data Use Policy
Coded Events
Identifiers
Coded Results
Restricted By PI
PI Only
Active Protocols
Sharable Through PI
PI Only
Unencumbered By PI
No Access
Inactive Protocols
Collaborative with PI
9. Data may move back to be considered active if
a PI (not necessarily the original PI), gets
approval to use the data, including (as per the
IRB), identifying information.
39BTRIS Data Use Policy
Coded Events
Identifiers
Coded Results
Restricted By PI
PI Only
Active Protocols
Sharable Through PI
PI Only
Unencumbered By PI
No Access
Inactive Protocols
Collaborative with PI
10. To summarize, PIs have access to data in
their own active protocols, subject to any
blocking that may be required.
40BTRIS Data Use Policy
Coded Events
Identifiers
Coded Results
Restricted By PI
PI Only
Active Protocols
Sharable Through PI
PI Only
NIH Community
Unencumbered By PI
No Access
Inactive Protocols
Collaborative with PI
11. The NIH community will have access to all
data, except identifiers, with restrictions on
data (active or inactive) by PIs. Restrictions
may differ for events versus results.
41User Requirements
- 2006 study of user requirements
42User Requirements
- Provide Medication lists at time of patient
encounters. Include drug diaries for inpatient,
outpatient and in-between encounters in the
patient medical record. Include all chemo and
non-chemo drugs from CRIS and IC systems - Provide Medication administration documentation
(drug diaries) with times as part of patient
record - Provide ability to compare patient results,
Medication Administration Records between dates
and/or encounters - Provide drug randomization info, compliance
records and drug accountability info for all
investigational, study and prescription drugs - Provide all Clinical Center lab results with
times of specimen draws - Provide external lab results
- Provide archival images
- Provide demographics data including age, BMI,
race, gender, contact info, etc - Provide access to genomics and bio-markers data
- Provide cumulative blood volumes, research drugs
and radiation for subject over a given period - Provide ability for ICs to feed expanded
diagnosis/problem lists - Provide searching and filtering patients' data by
all diagnosis, tests, procedures, protocol
protocol classifications
- Standardize medication and lab test codes.
- Provide integration of adverse events data in the
data warehouse, - Provide integration of protocol census, status
and subject accrual tracking data from Protrak in
the data warehouse - Provide ability to attribute different events to
protocols, viz., consent signed, protocol
activated, orders, observations, adverse events,
etc - Provide integration of staff, patient and user
index data across source systems in data
warehouse. - Provide original informed consent, and updated
consents for re-contact of patients for research
for all protocols. Provide searchable consents
and image of consents in database. Provide
answers to - Can tissues be used for cancer/genetic research,
other research, germ line testing - Can patient be re-contacted for questions?
- Provide single patient amendments
- Provide access and track biological specimen data
- Provide access to Appointment Data
- Provide Review of Systems info for each patient
visit. - Provide patient de-identification services
- Standardize Units Of Measure
43User Requirements
- 2006 study of user requirements
- Investigator User Group
- Demos
- To user group
- One-on-One
- Town hall meeting
44User Access/User Interface
- Canned reports (e.g., recruitment for IRB)
- Reports with prompts (e.g., sets of lab results)
- Ad hoc queries (whatever you want!)
- Selected Business Objects
45Terminology-Based Queries
- Hripcsak G, Allen B, Cimino JJ, Lee R. Access to
Data Comparing AccessMed to Query by Review.
Journal of the American Medical Informatics
Association 19963(4)288-299.
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47Terminology-Based Queries
- Hripcsak G, Allen B, Cimino JJ, Lee R. Access to
Data Comparing AccessMed to Query by Review.
Journal of the American Medical Informatics
Association 19963(4)288-299
- Business Objects prompt with hierarchy
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49Terminology-Based Queries
- Hripcsak G, Allen B, Cimino JJ, Lee R. Access to
Data Comparing AccessMed to Query by Review.
Journal of the American Medical Informatics
Association 19963(4)288-299. - Business Objects prompt with hierarchy
- Ancestor-descendant join with filtering
50Ancestor-Descendant Joinwith Filtering
- Start with parent-child table
- Transitive closure produces ancestor-descendant
table - Designate subset of searchable classes
(ancestors) - Display flat list (no tree walk)
- Let user select desired classes
- Query selects ancestor-descendant rows and joins
data tables based on descendants
51Status
- Modeling source data
- Clinical Research Information System
- Clinical Data Repository
- Crimson (NIAID)
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53Status
- Modeling source data
- Clinical Research Information System
- Clinical Data Repository
- Crimson (NIAID)
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57Status
- Modeling source data
- Clinical Research Information System
- Clinical Data Repository
- Crimson (NIAID)
- Unified BTRIS data model
- Database versions
- Specific for principal investigator
- Scrambled data for general use
- Business Objects demonstration
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69BTRIS in the Research Process
Scientific Review
Analysis of Resources Required
Write Protocol
IRB Approval
Hypothesis Generation
Recruitment
Publications
Patient Accrual
Data Gathering And Analysis
70Next Steps
- Rebuild database in Oracle
- Total historical data sets from CDR, CRIS,
CRIMSON - Live interfaces with Lab, Radiology, CRIS and
CRIMSON - Continue to collect user feedback
- Develop report sets
- BTRIS 1.0 - July 2009
71More Issues
- Patient ownership of de-identified data
- If genomic data are included, can we truly
de-identify? - Is protocol number a patient identifier?
- How important is protocol attribution?
- What data should not be shown to PIs?
- What is the extent of data control by PIs?
72Moving Forward
- Despite centuries of clinical research, data are
still fragmented - Sophisticated terminology is the key to reuse of
disparate data - Policy issues are bigger than technical issues
73BTRIS Will
- Be the preferred system to analyze NIH clinical
and non-clinical data - Aggregate and standardize disparate and isolated
data sets - Automate and streamline processes that are
traditionally manual and cumbersome - Prioritize data sources and functionality based
on needs of user community - Future of BTRIS today the NIH, tomorrow the
world?
74btris.nih.gov