Exploration of the Brain

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Exploration of the Brains White Matter Pathways
with Dynamic Queries

• David Akers, Anthony Sherbondy,
• Rachel Mackenzie, Robert Dougherty, Brian Wandell
• Stanford University

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The Human Brain
Williams et al., Iowa Virtual Hospital
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The Human Brain
Williams et al., Iowa Virtual Hospital
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The Human Brain
Williams et al., Iowa Virtual Hospital
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Diffusion Tensor Imaging (DTI)
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DTI Path Tracing
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DTI vs. Anatomy
?

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DTI vs. Anatomy
?

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DTI vs. Anatomy
?

Vilanova et al. 04
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DTI False Negatives
Woolsey et al. 03
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DTI False Negatives
Woolsey et al. 03
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DTI False Negatives
Woolsey et al. 03
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DTI False Negatives
Woolsey et al. 03
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DTI False Negatives
Woolsey et al. 03
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DTI False Negatives
Woolsey et al. 03
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Visualization Goals

• With DTI
• Possible to identify known connections?
• Possible to hypothesize new connections?
• How to compare connection candidates?

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DTI Visualization Techniques
Glyphs
Volume Rendering
Path Tracing

• Mori et al. 99
• Conturo et al. 99
• Weinstein et al. 99
• Lazar et al. 01
• Zhukov et al. 01

• Kindlmann et al. 99, 00

• Westin et al. 02
• Kindlmann et al. 04

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Path Tracing Complexity
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Dynamic Queries
TimeSearcher Hochheiser and Shneiderman 2001
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What if ?
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Implementation

• Precomputed all pathways, statistical
  properties!
• Efficient path intersections OBB-Trees (RAPID)
• Gottshalk et al., 1996
• Written with C, VTK, wxWidgets

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Discussion
?
?
?
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Future Work

• Anatomical VOIs
• Surface-constrained VOIs
• Integration of fMRI, other modalities

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Future Work

• Anatomical VOIs
• Surface-constrained VOIs
• Integration of fMRI, other modalities

Woolsey et al. 03
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Future Work

• Anatomical VOIs
• Surface-constrained VOIs
• Integration of fMRI, other modalities

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Future Work

• Anatomical VOIs
• Surface-constrained VOIs
• Integration of fMRI, other modalities

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Future Work

• Anatomical VOIs
• Surface-constrained VOIs
• Integration of fMRI, other modalities

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Acknowledgments

• Roland Bammer, Mike Moseley (Stanford Lucas Ctr)
• Pat Hanrahan, Jeff Klingner
• This work was supported by two funding sources
• NSF Graduate Research Fellowship
• NIH NIGMS Scientist Training Fellowship

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The End
http//graphics.stanford.edu/projects/dti/