Immuno or Targeted Liposomes

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Immuno or Targeted Liposomes
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Immuno or Targeted Liposomes
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Immuno or Targeted Liposomes
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Doxil Liposomal Doxrubicin for IV Infusion

• Doxrubicin 20 mg
• MPEG-DSPE 31.9 mg
• Fully Hydrogenated Soy PC 95.8 mg
• Cholesterol 31.9 mg
• Histidine as buffer
• Sucrose
• D. W. for injection q.s. to 10 mL

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Stealth Liposomes
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Enhanced Permeation and Retention (EPR) Effect
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Enhanced Permeation and Retention (EPR) Effect
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Doxil Liposomal Doxrubicin for IV Infusion
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Lipoplatin Liposomal Cisplatin

• Cisplatin
• MPEG2000-DSPE
• Fully Hydrogenated Soy PC
• Cholesterol
• DPPG
• Mean Diameter 110 nm

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Lipoplatin
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Lipoplatin
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Lipoplatin

• The cytotoxicity of Lipoplatin is substantially
  reduced compared to Cisplatin, which means that
  higher concentrations can be administered
• Lipoplatin stays in circulation for extended
  periods of time and the Cisplatin is slowly
  released
• Lioplatin can selectively target tissues with
  altered vascularization, therefore targeting
  primary tumors and metastasis this reduces the
  overall toxic effects on normal tissues

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DaunoXome Daunorubicin citrate liposome injection

• DSPC (10) 704 mg
• Cholesterol (5) 168 mg
• Daunorubicin (1) 50 mg
• Sucrose 2.125mg
• Glycine 94 mg
• Calcium Chloride Dihydrate 7 mg
• Mean Diameter 45 nm
• Vd 6.4 (1006)
• T1/2 4.41 (0.77)

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Amphotericin B (AmB)
      

• AmB a natural fermentation product from
  Streptomyces nodous
• Consist of a large, amphipathic macrolide lactone
  ring that presents seven conjugated double bonds
  on one side and seven polar hydroxyl groups on
  the other side

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Amphotericin B

• Insoluble in water, slightly soluble in methanol
  (around 0.5 mg/ml) , soluble in DMSO (30-40
  mg/ml).
• Broad-spectrum antifungal activity
• Antifungal of choice for the treatment of
  life-threatening infections, despite sever acute
  and chronic toxicity, including dose-limiting
  nephrotoxicity
• LD50 in mice, i.v. 4 mg/kg, i.p. 88 mg/kg

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Amphotericin B

• AmB acts by binding to the sterol component of a
  cell membrane, forms pores or channels in
  sterol-containing membranes, which changes
  permeability of cell membrane and causes leakage
  of protones, monovalent cations and other cell
  constituents leading to cell death.
• The affinity of AmB for ergosterol (the primary
  sterol of fungal membrane) is almost 10-fold
  higher than cholesterol (the primary sterol of
  mammalian membrane)