Interventional MRI Magnetoencephalography

1
Interventional MRIMagnetoencephalography
Verification of Functional Imaging with
Interventional MRI Mapping of Epilepsy and
Eloquent Cortex
2
Steven Stufflebeam, M.D. (MGH)Ronald Kikinis,
M.D. (BWH)
Partners Radiology Research Award
3
Interictal Spike Localization
MEG
4
Brain Connectivity
Structural Connectivity DTI Tractography
Greg Sorensen
Functional Connectivity BOLD fMRI
Vincent Buckner, 2006
Effective Connectivity MEG dynamic SEM
Fa-Hsuan Lin
5
Combining Advanced Imaging Technologies Sum is
greater than the Parts
Tumor, MEG, MRAngo, DTI fMRI
Stephen Piper, Ph.D.
6
Language Mapping in Temporal Lobe Tumor
T2 MRI Tumor
Isopoential Field Maps (MEG)
DTI
MEG Dipole For Language Stimuli
C
Dr. Alexandra Golby Dr. Ralph Suarez Dr. Ronald
Kikinis. Dr. Stufflebeam
7
Dr. Alex Golby Dr. Ralph Suarez. Dr. Stufflebeam
8
Why is this research important?

• Translational research bench to bedside.
• Multidisciplinary and cross-institutional
  Physics, software engineering, mathematics,
  neurosurgery, neurology.
• Leverages the resources of the BWH MGH to
  advance researchdirectly to patients/physicians.
• 250 epilepsy brain tumor patients from MGH/BWH
• Awards at ISCAMEG, HBM, ISB
• HST.583 Imaging Biophysics Clin Apps
• Grants R01, P41, K08, K25, CIMIT

9
Thanks

• BWH

• MGH/Martinos Center

• Ron Kikikis
• Stephen Piper
• Ferenc Jolesz
• Ralph Suarez
• Alexandra Golby
• Joseph Madsen
• Ed Bromfield
• Barabara Dworetzky
• Jong Lee

• Emad Eskandar
• Reese Cosgrove
• Andy Cole
• Ronan Kilbride
• Matti Hamalainen
• Fa-Hsuan Lin
• Greg Sorensen
• Randy Buckner
• Gordon Harris
• Giorgio Bonmassar