Krebs Cycle and the Mitochondria

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Krebs Cycle and the Mitochondria
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• The mitochondria is found in eukaryotic cells and
  not prokaryotes
• The mitochondria has its own DNA (circular) and
  proteins. The only other organelle is the
  chloroplast.
• The mitochondria has three parts outer membrane,
  inner membrane and matrix
• The outer membrane is permeable to pyruvate.

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• Pyruvate must be transported across the inner
  membrane of the mitochondria.
• The enzyme complex pyruvate dehydrogenase
  converts pyruvate into acetyl-CoA.
• Pyruvate dehydrogenase consists of multiple
  copies of three enzymes pyruvate dehydrogenase,
  dihydrolipoyl transacetylase and dihydrolipoyl
  dehydrogenase.
• Converting pyruvate to acetyl-CoA requires NAD
  to NADH

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• The Krebs cycle generates one ATP or GTP, one
  FADH2 ,two carbon dioxides, three NADH all from
  one pyruvate.
• Amino acids and fatty acids can be converted into
  acetyl-CoA for entry into Krebs cycle
• Alpha ketoglutarate can be converted into amino
  acids, heme, nucleic acids
• Citrate can be converted into fatty acids

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