Dangerous Liaisons: Drugs that Interact

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Dangerous LiaisonsDrugs that Interact

• Robin OBrien PharmD

Pharmacotherapy Consulting Group ? 2005
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The drug most commonly involved in a significant
drug-drug interaction in community pharmacies is
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3
A drug interaction allert appears when warfarin
is dispensed for the first time to a patient
taking levothyroxine. The appropriate
intervention is
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4
Pharmacists should always check interactions
involving
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5
Action is required with PharmaNet severity
level(s)
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Cytochrome P450 isoenzymes are responsible for
interactions occurring primarily in the process of
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Cytochrome P450 isoenzyme deficiencies are found
in
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P-glycoprotein (PGP) causes multi-drug resistance
because it is a
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PGP creates a protective barrier to drug
penetration at which sites
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PGP can affect serum concentrations of drugs by
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Cranberry juice is most likely to interact with
warfarin to
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Dangerous Liaisons Drugs that Interact
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