A1258690456yEfZJ

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Lymphopoiesis and the Functional Anatomy of
Lymphoid Tissues

• Lymphopoiesis
• Lymph Nodes
• Spleen
• Thymus

• Reference Material
• 1) Objectives and Notes
• Hoffbrand chapters 1 and 10
• Still have questions? lebrun_at_cliff.path.queensu
  .ca

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naïve
germinal center
B-lymphocytes
Plasma cells
Lymphoid progenitor
T-lymphocytes
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Primary lymphoid tissues bone marrow and
thymus Secondary lymphoid tissues lymph nodes,
spleen and lymphoid tissues of the gut, mucosal
surfaces, respiratory tract and skin
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From Dr. Basta's lecture
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From Dr. Basta's lecture
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Stages of B-lineage Maturation
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The Germinal Centre Reaction
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Lymph Node Structure
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B-cell stain
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The Spleen
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Red Pulp
White Pulp
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• Functions of the Spleen
• Removal of unwanted elements from the blood
• Secondary organ of the immune system
• Hematopoiesis
• Reservoir for blood cells and platelets

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The Thymus
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Thymic Involution
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naïve
germinal center
B-lymphocytes
Plasma cells
Lymphoid progenitor
T-lymphocytes