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THE RATE OF RBC PASSAGE THROUGH A NARROW PORE AS
A FUNCTION OF CELL VOLUME
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Step 1 Database and physiological analysis

• The main physiological task of the erythrocyte
  is
• to stabilize its volume

• The main control characteristic is the
  dependence
• of cell volume on membrane permeability.

Good
Bad
Stabilization
3
Na-pump
Na,K-pump
VOLUME V/V phys
PERMEABILITY G/G phys
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Cell membrane

Red Blood Cell
Ca
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Na-pump
Na,K-pump
Ca-activated K-channel
VOLUME V/V phys
PERMEABILITY G/G phys
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Cell membrane
Red Blood Cell
Ca
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Rate of glycolysis
ATP concentration energy charge
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Step 3. Key steps of metabolism
Hexokinase and phosphofructokinase catalyze the
key reactions in energy metabolism of the
erythrocytes
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Cell membrane
Ca
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VOLUME V/V phys
PERMEABILITY G/G phys
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Triosephosphateisomerase activity
Enzyme activity ()
Critical Enzyme activity (cell death)
Age of Red Blood Cells (days)