Hepatic Drug Metabolizing Enzymes and Specific AED Interactions - PowerPoint PPT Presentation
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Hepatic Drug Metabolizing Enzymes and Specific AED Interactions
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Inhibitors: valproate, ticlopidine, fluoxetine, topiramate, fluconazole. Carbamazepine CYP3A4 CYP2C8 CYP1A2. Inhibitors: ketoconazole, fluconazole, erythromycin, ... – PowerPoint PPT presentation
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Title: Hepatic Drug Metabolizing Enzymes and Specific AED Interactions
1
Hepatic Drug Metabolizing Enzymes and Specific
AED Interactions
- ? Phenytoin CYP2C9 CYP2C19
- Inhibitors valproate, ticlopidine, fluoxetine,
topiramate, fluconazole - ? Carbamazepine CYP3A4 CYP2C8 CYP1A2
- Inhibitors ketoconazole, fluconazole,
erythromycin, diltiazem - ? Lamotrigine UGT 1A4
- Inhibitor valproate
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