Modeling Oscillating Neurons in Respiratory Rhythmogenesis

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Modeling Oscillating Neurons in Respiratory
Rhythmogenesis
Connie Oh
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preBotzinger Complexsite of rhythm generation
Looking for inspiration new perspectives on
respiratory rhythm Jack L. Feldman and
Christopher A. Del Negro Nature Reviews
Neuroscience 7, 232-241 (March 2006)
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Hodgkin-Huxley (1952)

• V (- 1/c) iapp gNam3h(V ECa)
• gKn4(V EK) gleak(V Eleak)
• m am(V)(1 m) - ßm(V)(m)
• h ah(V)(1 h) - ßh(V)(h)
• n an(V)(1 n) - ßn(V)(n)

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Fitzhugh-Nagumo (1962)

• ? v v(v a)(1 v) w
• w v bw c

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Morris-Lecar (1981)

• V (-1/c) iapp gleak(V Eleak)
• gKw(V - EK) gCam8(V)(V ECa)
• w f w8(V) w / tw(V)

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Novel Model

• V - (1/c) iapp gleak(V Eleak)
• gNa(V ECa) gK(V EK)
• gCa(V ECa) gsyn(V Esyn)
• gton(V Eton) gCaf(Ca)(V ECa)

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ca0.50.40.30.20.10-0.1-0.2V0-10-20-30-40-50-60