Integrated biorefinery workshop: Dutch perspective

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Integrated biorefinery workshopDutch perspective

• Ruud A. Weusthuis, René van Ree

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From RD to Products needs, barriers and
solutions

• Biorefinery
• Fermentation in theory powerful tool
• Many complex reactions in one step
• Ambient temperatures, pHs and pressures
• Versatile in feedstock utilization and product
  formation
• Genetic engineering
• However, often also
• Low yields (0.5 g/g)
• Low productivities (1-2 g/l/h)

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Industrial fermentation processes
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From RD to Products needs, barriers and
solutions

• Need
• Efficient fermentation processes with high yields
  and productivities
• Barrier
• Productivity oxygen transfer or associated heat
  generation
• Yields Biomass and CO2 production (both
  stimulated by oxygen utilization)

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From RD to Products needs, barriers and
solutions

• Contemporary solutions
• Productivity pure oxygen in stead of air, higher
  aeration rates, higher stirrer speeds, higher
  pressures stainless steel engineering
• Yields metabolic engineering
• Results marginal

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From RD to Products needs, barriers and
solutions

• Break through solutions
• No oxygen!
• Calculation show that simultaneous production of
  lysine and glutamate results in 40-90 yield
  increase, no oxygen requirement.
• In theory applicable to all combinations of
  reduced and oxidized products
• Other possibilities
• New, patented needs further development