BC10M: Introductory Biochemistry, 2005 Semester 2'

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BC10M Introductory Biochemistry, 2005 Semester 2.

• Friday 18 Mar.
• Lecture 26
• Krebs cycle
• Andrew Pearson

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Krebs cycle, a.k.a. Tricarboxylic acid cycle
Citric acid cycle
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The purpose of the Krebs cycle is to extract the
maximum number of electrons from acetylCoA, and
send them to the electron transport chain to
drive proton pumping.
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Catabolism of all major food groups can lead to
Acetyl CoA
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Citrate synthase
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Aconitase
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Isocitrate dehydrogenase
(As NADH)
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a-keto-glutarate dehydrogenase
(As NADH)
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Succinyl CoA synthetase
(GDP ? GTP)
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Succinate dehydrogenase
(As FADH2)
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Fumarase
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(As NADH)
Malate dehydrogenase
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