Ross Lab Biophysics

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Ross Lab - Biophysics

• Biophysics
• Study of Physical Properties of Biological
  Systems
• Using Physics Techniques to Study Biological
  Systems
• Cytoskeleton Rich Biological System of Interest
• Microtubules Shape the Cell
• Motor Proteins Move Objects and Microtubules

Microtubule Cytoskeleton
Microtubule and Motor
Zoom 2500x
4 nm
Cartoon Dynein with Cargo on Microtubule
Green Microtubules Blue DNA
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Ross Lab - Biophysics

• Single Molecule Biophysics of Microtubule Motors
• Dynein, Katanin, Ncd Kinesin, Destabilizing
  Kinesin-14 Family
• Using Total Internal Reflection Microscopy with
  Polarization
• Optical trapping of motors to measure force
• Non-Equilibrium Pattern Formation with
  Microtubules and Motors
• Microtubules, Microtubules and Motors,
  Microtubule-Associated Proteins
• Static Confined Spaces (Lithography),
• Deformable Confined Spaces (Vesicles and Emulsion
  Drops)
• Building Projects
• Microfabrication projects
• All Microscopy Biochemistry

Ross, et. al., in review
Nedelec, et. al., Nature 1997
Website www.physics.upenn.edu/rossje Email
rossje_at_mail.med.upenn.edu