SLA Spring Meeting

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SLA Spring Meeting 8th April 2008St
Petersburg, FloridaSean McDonnell
sean.mcdonnell_at_informa.com212-520-2786
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Introduction

• Global RD pipeline database in development since
  1980
• 41,000 full drug profiles (9144 active)
• 3100 private and public company profiles
• 218 detailed therapy profiles
• 1645 Searchable targets and target families
• 16,000 complete chemical structures
• 34 Full-time Pharmaprojects scientific editors
  (based in Europe, US and India)
• Over 200 contributing editors

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Information Sources

• News feeds and Press Releases
• Company Web sites, fact sheets Annual reports
• Meetings abstracts (covered 140 medical
  investor meetings in 2007)
• Editorial contacts within companies - 6039 drugs
  (15) have direct communication data in profile
• Other Informa products Scrip, TrialTrove,
  Clinica, Datamonitor
• Online resources EntrezGene, PubMed, Espacenet,
  FDA
• Peer reviewed journals
• FDA and SEC filings
• Published Trials Results
• Public trials registries (clinicaltrials.gov,
  cancer.gov)
• Company Conference calls with analysts

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Unique Features

• Functionality and specificity
• 75 fields of searchable and exportable data
• Established reputation for high quality
  information
• 28 years of RD data collection
• Innovative and original content
• Trend Analysis Annual data from 1995 to 2008,
  which can be searched to see how RD patterns are
  shifting.
• Pharmaprojects Rating system Internal
  benchmarking program
• Target Families - Grouping together protein
  targets by activity
• More than just a database
• Fully customised and consultative training
  programme
• Complete access to all Pharmaprojects scientific
  editors

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75 fields

• Generic Name, Synonyms, Active Ceased or Fully
  Launched, Accession Number, Detailed Information,
  Clinical Information, Clinical References, World
  Status, Originator, Originator Country,
  Originator Status, Licensee, Licensee Country,
  Licensee Status, Primary Therapy Code, Primary
  Therapy Description, Primary Therapy Status, Any
  Therapy Code, Any Therapy Description, Any
  Therapy Status, Link Pharmacology Code, Primary
  Pharmacology Code, Primary Pharmacology
  Description, Any Pharmacology Code, Any
  Pharmacology Description, Link Therapy Code,
  Primary Indication, Primary Indication Status,
  Any Indication, Any Indication Status, Primary
  ROA Code, Primary ROA Description, Any ROA Code,
  Any ROA Description, Target FamilygtGroupgtSubgroup,
  EC Number(s), Primary Target Name, Primary
  LocusLink/Entrez Gene ID, Any Target Name, Any
  LocusLink/ Entrez Gene ID, Origin of Material
  Code, Origin of Material Description, CAS Number,
  Rotatable Bonds, Hydrogen Bond Acceptors,
  Hydrogen Bond Donors, AlogP, Molecular Weight,
  Chemical Name, Chemical Structure, New Chemical
  Entity, Patent Country, Patent Number, Patent
  Priority Country, Patent Priority Date, Country
  Status, Country Name, Licensing Opportunity,
  Novelty Rating, Novelty Rating Description,
  Market Size Rating, Market Size Rating
  Description, Speed Rating, Speed Rating
  Description, Total Rating, Major Event, Major
  Event Details, Major Event Date, Act/Est, Last
  Updated On, Updated By, Latest Change

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Powerful analytical Interface

• Searching
• Ability to create both simple and complex Boolean
  logic searches
• Access to previously saved searches
• Wildcard, proximity and free text searching
• Exporting
• Fully customized report tables (HTML, Excel,
  BizInt, SDF)
• Full drug, company and therapy profiles (MS Word,
  Rich text, HTML)
• Graphs and charts
• Import/export chemical structures for exact,
  sub-structure similarity searching (Chemdraw,
  CAS,CXF, ISIS, MDL, SMD, SMILES)

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Innovative and Original Content

• Trend Analysis
• Annual snapshot of Pharmaprojects data, inc
  company pipelines, therapies, country status
  mechanism of action

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• Pharmaprojects Ratings system
• Internal ratings system designed to predict
  blockbuster compounds of the future, using 3 key
  criteria
• Market -based on the reported worldwide sales (in
  US million) for its primary therapeutic
  category.
• Novelty -uses Pharmaprojects' pharmacological
  classification system in combination with the
  therapeutic classification to identify which new
  drug development strategies are the most
  advanced.
• Speed Uses calculated averages to benchmark the
  speed in which a compound moves through the
  development stages and determine its progress.
• Compounds are then rated 1-15 based on this
  information

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Target Searching

• There are 1645 unique protein targets (1514
  human)
• 719 correspond directly to pharmacologies
• 44 of all PP records have real targets (i.e.
  not unspecified/NA etc)
• Full links from all drug records to Entrez Gene
  database

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Links to Entrez Gene

• Drug target database developed by NCBI
• Collates data on genes and proteins from many
  reputable sources, including GenBank, SwissProt,
  Unigene, OMIM and PubMed
• These profiles describe target properties and
  contain a large number of useful links, including
  sequence links, OMIM for detailed background
  information, PubMed references, Gene Ontology
  classes and KEGG pathways

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Target Families

• Classified all drug protein targets into 6 main
  categories, based on general activity.

• Cytokine/Growth factor
• Enzyme
• Ion channel
• Peptide hormone
• Receptor
• Transporter
• It is then possible to drill down by a further
  3 levels of specific target activity.
• Example
• (Parent) Receptor
• gt (Child) GPCR
• gt (Grandchild) Angiotensin
• gt (Target) angiotensin II receptor, type 1
• gt (Target) angiotensin II receptor, type 2

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Links to Scrip

• Scrip World Pharmaceutical News is a news
  service, which
• delivers an unrivalled range of pharma market
  intelligence.

• Pharmaprojects analysts access Scrip Daily News
  Online stories on a daily basis in order to
  update information appearing in Pharmaprojects
  drug profiles.
• For all articles published since January 2001,
  Pharmaprojects provides links from the Scrip
  Daily Online references given in the
  Pharmaprojects drug profile to the full news
  story from Scrip Pharmaceutical News completely
  free of charge.

• In clicking the Scrip hyperlink, the full text
  article will be displayed.

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Links to Pubmed
PubMed is a service of the U.S. National Library
of Medicine that includes over 17 million
citations from MEDLINE and other life science
journals for biomedical articles back to the
1950s. PubMed includes links to full text
articles and other related resources.

• Our editors review new PubMed citations on a
  daily basis and with each item of data sourced,
  we provide a hyperlink to the relevant article.

• In PubMed you can access more bibliographic
  information by using the list of further links to
  related articles, and access a range of
  background information.
• We have added more than 1,000 PubMed links to
  Pharmaprojects already, and are increasing this
  number weekly.

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More than just a database...
Pharmaprojects is more than just a database - we
provide a research service, offering immediate
access to our team of scientific analysts in both
the UK and the US to schedule bespoke training
and offer research and search assistance as
required.

• The background and contact details of each of
  our scientific analysts can be found on our
  websites meet the team page.
• Clients can simply call or email our editors at
  any time to get search assistance or to schedule
  training.
• We offer both introductory and ongoing training
  with editors in London or New York, to suit our
  clients time zones.

• Clients can also contact the editor responsible
  for a specific update by clicking the hyperlink
  to the editors initials, located in every drug
  profile.

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Pharmaprojects Website

• Pharmaprojects launches new web site with free
• news and analysis for the pharmaceutical industry

• excellent portal for both subscribers and
  non-subscribers, offering access to detailed
  company and therapy analyses and pharmaceutical
  news articles, written frequently by our team of
  scientific analysts.

• Read reports from various scientific and
  partnering conferences around the world.
• Offers a quick and easy way to access search
  tips, technical support, or to arrange training
  with one of our scientific analysts.
• To keep visitors up-to-date with the latest
  cutting-edge research, there are also short
  articles on the most recently-identified drug
  protein targets and emerging start-up pharma
  companies.

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TrialTrove

• Informa Healthcare purchased the Citeline
  business in November 2006.
• TrialTrove is Citelines flagship product and is
  the leading source for real-time clinical trials
  intelligence.
• Enterprise-wide system
• Over 70,000 trial records
• Real time updates
• Watch lists
• Analyst research requests

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TrialTroves Additional Sources

• Information not from obvious sources that gives
  you an edge
• Patient Recruitment Channels
• research center and community hospital web sites
• Clinical Research Administration
• University protocol/IRB approval lists and grant
  awards lists
• Investigator CVs
• CRO project listings
• Primary Research
• 13,000 unique cited Web sources in TrialTrove
  today!

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Trialtrove Pharmaprojects collaboration

• Shared editorial practices, sources and company
  contacts.
• Synchronized databases to fill in data gaps and
  add missing drugs
• Standardised field definitions and mechanism of
  action descriptions.
• And the initial impact of this on
  Pharmaprojects?...
• More efficient and timely editorial updates
• A 20 increase in the number of active products
  since 2007
• And the development of our new product - Pipeline

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Pipeline

• This new service launched in January 2008
• Enterprise wide access
• Pharmaprojects data combined with the
  functionality, ease of use and unlimited client
  service enjoyed by TrialTrove customers
• Over the coming months we will be in contact with
  our customers to present this service in detail
• For further information
• Sean.mcdonnell_at_informa.com 212-520-2786