ECHA the Danish Sample

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ECHA - the Danish Sample

• Karen Andersen-Ranberg
• Gitte Bay Christensen
• Kirsten Rasmussen
• Bernard Jeune
• Axel Skytthe
• Epidemiology,
• Institute of Public Health
• University of Southern Denmark

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Selection procedure I

• Proband P(I)
• Women born before 1905 98 years
• Men - - 1908 95 years
• Siblings to proband C(I)
• Sister Brother
• Concordant sib aged 94 88
• Discordant sib aged 60 -79 55 - 74
• ) Siblings born between 1890 and 1915
• ) Both proband and sib must have at least 1 child
  living

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(No Transcript)
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Study base

• Number of persons fulfilling proband criteria
• (youngest cohort 1907)

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From study base to interview( GI ) January 1,
2004
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From interview to ECHA proband P(I) January 1,
2004
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Progress on G(I) interviews

• Approx. 450 members of study base have been
  handled
• More than 160 G(I) interviews performed
• Funen and Vejle counties almost done
• Ribe and S. Jutland ongoing
• Inclusion of men born 1908 ongoing (additional
  124 study base members)

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Selection procedure II

• Generation II
• Child of proband P(II)
• Child closest to age 75 is chosen
• Child of siblings C(II)
• Same sex as P(II)
• Smallest age difference between P(II) and C(II)
  maximum 10 years
• If both concordant and discordant choice is
  possible, random shift between concordant and
  discordant choice

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Examples of large families without ECHA pairs - I
? 79
? 60
? 69
? 89
? 80
? 71
? 95
42-224
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Examples of large families without ECHA pairs - I
? 79
? 60
? 69
? 89
? 80
? 71
? 95
42-224
11
Examples of large families without ECHA pairs - I
? 79
? 60
? 69
? 89
? 80
? 71
? 95
42-224
12
Examples of large families without ECHA pairs - I
? 79
? 60
? 69
? 89
? 80
? 71
? 95
Not found
?
?
?
?
?
?
?
?
?
? 74
42-224
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Examples of large families without ECHA pairs - I
? 79
? 60
? 69
? 89
? 80
? 71
? 95
42-224
14
Examples of large families without ECHA pairs - I
? 79
? 60
? 69
? 89
? 80
? 71
? 95
? ?
? 66
? 69
? 72
42-224
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Examples of large families without ECHA pairs - II
? 97
? 85
? 79
? 74
? 56
? 99
? 2
42-254
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Examples of large families without ECHA pairs - II
? 97
? 85
? 79
? 74
? 56
? 99
? 2
42-254
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Examples of large families without ECHA pairs - II
? 97
? 85
? 79
? 74
? 56
? 99
? 2
1888-1985
42-254
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Examples of large families without ECHA pairs - II
? 97
? 85
? 79
? 74
? 56
? 99
? 2
Sweden
Norway
? 78
? 80
? 0
? 75
42-254
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Examples of large families without ECHA pairs - II
? 97
? 85
? 79
? 74
? 56
? 99
? 2
? 78
? 80
? 0
? 75
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Examples of large families without ECHA pairs - II
? 97
? 85
? 79
? 74
? 56
? 99
? 2
NO
? 78
? 80
? 0
? 75
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ECHA proband in G(I) gt ECHA pairs in G(II)
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Progress on G(II) interviews

• 134 interviews on G(II) individuals done
• 86 children of proband
• 48 cousins
• Age range of G(II) interviewed persons are 52
  80 years, mean age 67.5 years

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Conclusion

• Prediction in June 2003
• 10 of the P(I) study base will be included as
  ECHA members
• On January 1, 2004
• 421 P(I) study base members from Funen and Vejle
• 43 full pairs including P(I) with child and
  cousin from G(II)

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Future ...

• Inclusion of one more county (Aarhus or West
  Zealand) to reach a sufficient number of ECHA
  cousin pairs
• Time schedule for data collection
• On time
• ? Data collection finished July 1, 2004