????? ?????- 3.5 ?????? ???, ????? ?????????

1
????? ????????????, ???????, ????????
2
????? ??????

• ????? ?????- 3.5 ?????? ???, ????? ?????????
  2.5 ?????? ???
• ?????? ?????????? (????? ???? ??????)- 40,000
  ???.
• ?????? ??? ??? 3 ?????? "??? ?????"

3
"?????? ??????"

• ?????? ?????? ???? ?????? (??? ??? ??????
  ??????).
• ?????? ?????? ??????? ???, ??? ??? ??????? ??????
  (??? ??? ?????? ?????).
• ????? ?? ??????? ??????, ?????, ??? ?????.
• ?? ????? ??' 3 ????!!

4
???????? ?????? ????? ????? ??????? ????? ??????
?????

• ???? ?????? ?????? ?????? ??????? ???? ??????
  ??????? ???? ??????? ??????? (EFA) ??????????
  (LC-PUFA).
• ?????? ?? ????? ?? ???? ???????? ???????? ??????,
  ???? ???????? ???? ???? ????? ??????? ???????,
  ????? CVD.

5
????????? ?? ???????

• ???? ????????? ????? ????? ?????? ????? ?????.
  ?????? ?????? ??????? ?? ?"?????? ?????????".
• ???? ?????? ?????? ?????? ??? ?????, ???? ?????
  ???? ???? ????? ?"?????? ?????????" ??????? ?????
  ???????.
• ????- ??? ????? ???????? ?? ???? ?????

6
The National Diet and Nutrition Survey, UK???
???? ???????...

• ????? 1.5-4.5
• 8 ?????
• 12 ?? ????? ????? ??? ?????
• 15 ?? ????? ????
• 8 ????? ??????? A
• 23 ????? ?- 2B
• 3 ????? ??????? C

www.food.gov.uk/science
7

• ????? ???"?
• 1.5 ?????? ?- 5 ?????? ?????
• 13 ?????? ?- 27 ?????? ?? ?????? ???? ?????
• 10 ?????? ?- 20 ?????? ????? ????
• ????? ??????, ??????? ??????? A ????? ????????.
• ???? ?? ????? ???? ?? 12B, C, D, ?????, ?????????
  ??????? ???.

8

• ????? 65 ?????
• 38 ????? ??????? D
• 38 ????? ??????? C
• 18 ????? ?????? ?????
• 15 ????? ??????? 12B
• 30 ????? ?????
• 11 ??????? ?- 9 ?????? ??????? ??? (?????
  ??????) ????? ?????.

9
??????? 2005...

• ????? ???????? ?????? ?????? ?????? 2-6 ?????
  ????? ????, ????, ???? ???? ????? ????? ???????
  ??????? ??????? ??? ??? ????.

10
????? ???? ????? ??????????? ?????? ?????????

• ???"? ???? 500 ?????? ???????? ??????? ??????
  ??????? ??????
• ???? ??? ????? ????? ????? ?????? ????,
  ?????????? ?? ?????? ??????.
• ??????? ?? ?????? ????? ?????? ??????? ????.

http//www.mentalhealth.org.uk/page.cfm?pagecodeP
RFMreports
11
????? ???? ????? ??????????? ?????? ?????????

• ??????? ???? ?? ????? ???? ??????? ?? ??????
  ?????? ????? ????????, ?????????, ?????????
  ???????, ?????? ?? ????? ??? ???????????.
• ??????? ?????? ??"?- ????? ?? ???? ???? ?????
  ????- ????? ????? 3 ????????? ???? ?????? 6 ????.

http//www.mentalhealth.org.uk/page.cfm?pagecodeP
RFMreports
12
You are what you eat- you act what you eat

• ???? ???????? ???? ?????? ???? ?????? ??????.
• ??? ??????? ????- ??????, ????? ????? ?????
  ??????.
• ???"? ??????? ????? ??????? ??????? ?????? ??????
  ??? ?- 2000 ????? ??????.

http//www.mentalhealth.org.uk/page.cfm?pagecodeP
RFMreports
13
?????? ???? ???????

• ????? ???? ?????? ???? ?? ?????, ????? ???? ??
  ?????? ?? ?????? ?????.
• ?? ???? ?? ???? ????? ??????? ????? ????????-
  ???? ?????? ?????
• ????? ????? ?????? ??????.
• ???? ?????? ???????, ??? ???? ????.

14
????? 3
?????? ????? 3 ???? ??????? ????? ??? ????.
?????? ???? ????? 3, ??????? DHA ?- EPA ??????
?????? ????????? - EFA. ??"? ??? ?????? 7 ?????
?? ????? ???? (????? 24 ???? ????).

• ?????? ????? 3 ???? ??????? ????? ??? ????.
• ?????? ???? ????? 3, ??????? DHA ?- EPA ??????
  ?????? ????????? - EFA.
• ??"? ??? ?????? 7 ????? ?? ????? ???? (?????
  24 ???? ????).

15
(No Transcript)
16
?????? ?????? ???? ???????? ???? ???????

• ????? ????? ??????? ????????? ?????? ???? ?????
  ?? ????????????.
• ???? ?????? ????? ??????? ????? ?? ??????
  ????????? ??? ????? ?????????????????.
• ??? ?????? ?- Second messenger ?????? ????????.
• ?????? ???? ?????? ?????? ????? ??????? ?? ??????
  ???? ?- Cell signaling.

17
(No Transcript)
18
????? EFA ?- LC-PUFA

• ??????? ??????? ????? ?? EFAs ?- LC-PUFAs
• ???? ???? / ????? (????)
• ????? ????????? ???????? (???)
• ????? ??????? ?????? ?????
• ??????? ????
• ????? ????????? ????? (???? ????, ??????)
• ??????? ?????? ?????????
• ??????? ????? ????? ????? ???????? ????????? ??
  EFA ?????? ???? ????? ??????? ??????? ???????????

19
??? 3?6? ?????

• ??? 41
• ?????? 10-141
• ???"? ??? 10.6-12.41
• ????? 22-261

20
???? ??? ??????? ??????

• ???? ????? ???? ?? 11-2.
• ????- 124 (??????).
• ???? ?????? ???? ?????? ??? ?? ????? ?????????
  ????? ????? EPA ?- DHA (???? ????? ????????).

21
?????? ?????? ????

• ?????? ???? ???? ????? 3 ?? ?????? ???? ???????.
• ?????? ?????? ????? ?? ?????? ???????? ?? ?? ??
  ?? ??? ????????? ?? ??? ????? ????? ?????? ??????
  ?? ?????.

22
????? ??????? ???? ??????? ????? ?

• ????? ??????
• ??????? ???????? ??? ??????? ??? ???
• ??????? ?????? ????? ???
• ????? ?????? ????????? ?? ???? ???
• ???????? ????
• ?????
• ????? ???????
• ????? ?????? ????????
• ????? ?????? ????? ??????

23
??? ?????? ????

• ????? 3 ?????? ???????? ?????? ????, ?? ????
  ???? ?????? ????????.

24
?? ????

• 60 ?????? ?? ?? ???? ??? ???????.
• ????? ????? ?????? ?????
• (??? ?-25) ??? ????? 3
• ????? Arachidonic Acid
• (?-20)
• ????? ???? ?? ?. ???? ?????

25
????? ?????

• ????? ?????? 3 ??????? ???????? ????? ?? ?????
  ?????? ????? ??? ?????, ?????? ???????? ??????,
  ?? ???? ???? ?????? ?? ?????.
• ?????? ???? ??? ??????? ???? ????? ????? ??????,
  ????? ????? ??????? ?????.
• NIH ????? ?? ????? ?? 300?"? ???? ?? DHA ?????
  ?????? ??????? ???? ?????? ?????? ??????? ????
  ???????? ??????? ????? ???? ???? ???? ???.
• ????? ????? ????"? ????? ?? ?????? ??????
  ??????? ?? DHA ??? ???? ?????? ????? 54?"? ????
  ????, ??? 2 ?????? ???? ???? ????? ?? ??????
  ???? ???.

26
????? 3 ??????)PEDIATRICS 2003)

• ????? ?????? 340 ???? ?????? ???? ??????
• ????? ??? ????? ???? ?? ????? 3 ??????? ????? ???
  ????.
• ?????? ????? ?-3 ?????? ?????.
• ?????? ????? ???? 4 ????.

27
?????? ?????

• ?????? ????? ???? 4 ????
• ???? I.Q ?????? ???? ???? ??? ?????? ?????????
  ???? ????? 3.
• ????? ???? ??????? ??? ???? ???? ??????? ?????.
• ?? ??? ????? ????? ????? ??? ??? ???????.

28
??? ?????? ????

• ????? ?? ?????? ????? ?????, ?????? ADD/ADHD,
  ???????? ?????????? ????????? ????? ?????? ??
  ????? 3 ????.
• ???? ??????? ???? ????? 3 ?????? ??????? ??????
  ???????, ????? ?????, ?????? ?????? ????.

29
????? ??? ADHD ?????? ??????? ????

• ????? ???? ?????? ?????? ?- LC-PUFA ???? ?????.
• ?????? ?? ADHD ?????? ????? ???? ?? ????? ????
  ?- LC-PUFA ????? ????? ????.
• ?????? ????? ???? ?? ?????, ??????? ?????? ?-
  ADHD- ?????? ??? ????? ?????? ??????
  Delta-6-desaturase ???? ??? ???? ?- EFA ?-
  LC-PUFA.

30
????? ??? ADHD ?????? ??????? ????

• ????????? ?????? ???? ???? ???, ???, ???????
  ?????? ?????? ?????? ?? ADHD- ????? ??????? ????
  ????? ?????? ??????? ?????, ?????? ????????,
  ????? ????? ???? ???'.
• ????? ???????????- ?????? ????? ???? ??????? ?-
  ADHD (44) ?? ????, ??????, ????? ???? ????.
  ????? ??? ?????? ???????? ?????? ???? ??? ?????
  ?- W3 ???????? ?????? ?????.

31
?????? EPA ?????? ????

• ?- EPA ?????? ??? ?????? ?????? ????????
  ????????????.
• DHA ??? ??? ????? ??? ????, ??? EPA ??????
  ?????? ???? ?? ????, ??????? ????? ?????.
• ??? ???? ?? EPA ?- DHA ???? ?????? ?? ??????
  ????? (??????).

32
OXFORD-DURHAM STUDY(PEDIATRIC 2005)

1. ????? ???? ?-117 ????? ??????? 5-12.
2. ?????? ????? ?-2 ?????? ???? ????? ??? ???? ?????
   3 ???? ????? 6 ??????? ????? ???? ????? ??? ???.
3. ???? ????? ??? ???? ?-cross over ???? ??????
   ????? ??? ??? ???? ???? ??? ?? ??????.

33
?????? ?????

• ???? ????? ????? ??????, ???? ???????? ???? 3
  ????? ?????
• ????? ??????- 80 ????? 28 ??????.
• ????? ????? 55 ????? 10??????.
• ????? ??????? ?????? ?????????? ??????? ?- ADHD.

34
???? ????

• ???? ?????? ?????? ????? ?? ?????? ????? ????
  ????.
• ????? ?????? ??????? ???? ?? ???????? ??? ?????
  ????.
• ????? ?? ??? ????? ?????????.
• ?????? ????? ?? ?????? ???? ??????? ???? ?????
  ?????? ?????? ??????? ??????.

35
?????? ?????

• ????? ??????? ???? ?? ????? ?? ?????? ????
  ??????? ???? ????? ?????? ?????? ??????? ??????
  ?????? ?? D.C.D.
• ????? ?? ???? ????? ?????????

36
?????? ????? ?????? ?????

• 6 W (??? ?? ?????)- ??? ???? ????????
• ????? DHA ???- ??? ???? ????????.
• ?????? EFA ????? ?????????? ????????
• ?????? EFA EPA ????? ????? ADHD.
• ???? ????? ?? ??? ???? ??? EPA ?- DHA.

37
????? ????? 3 ????? ??? ??? ???? ???

• ?? ????? ?????? ?????? ???? ????? 3 ??? ?????.
• ????? ??? ?????? ??? ?????? ???? ???, ?????? ????
  ?????.
• ???????? ????? ?????? ?????? ???????, ?????
  ?????????????, ????? ???????, ????? ?????
  ???????, ????? ????? ??????, ????? ?????? ??????
  ?????, ???? ????.

38
??????

• ????? 3 ??????- ???? ?? ???? ????? ??????? ????
  ???????.
• ?????? ?? ???? ??????? ?????? ????? ??????
  ???????.
• ?????? ?? ?????? ?????/ ADHD ?? ?????????? ??????
  ?? ????? 3.
• ????? ????? 3, ?????? EPA, ????? ?????? ????????
  ?????????.

39
????? 3 ?????? ????

• ???? ?? ?????? ?????? ????? ??????????? ??????
  ???? ??? ????? ?? ????? ????? (???? ?????) ??
  ?????????? ??????? ?????? ??????? ???.
• ?????? ?- FDA "??? ???? ?????, ????? ????? ???
  ???? ???? ????? ????? ????? ????? ??????. ?? ??
  ????? ???? ????? ?????? ??? ????? ?? ??? ?? ???
  ????? ??? ????? ???? ???? ???? ????? ????.
  ??????? ?????? ?????? ????? ??????, ?????? ??????
  ?????."
• www.fda.gov/bbs/topics/news/2004/NEW01038.html

40
????? 3 ??????? ?????

• ????? 3 ?????? ????? ????? ????? 3 ???? ?????
  ???? ???????, ????? ?"? ????? ???????? ?? ????
  ???? ????????????. ?????, ????? ????? ?????
  ??????? ?????? ??? ????? ?????? ?????? ????? 3.
• ???? ????? 3 ??? ???? ?- 30 ????? ??????? ?????
  ?? ????? ????? ????.
• ?- EPA ?- DHA ??? ???? ???????????? ?????? ?????,
  ?????? ?????? ??? ?????? ?? ??????? ????? ????
  ?"? ????? ?? ?? ?????????? ??? ?? ????????? ?? ??
  ?????.
• (Lipids. 200439(12)1177-85)

41
??????? ???????

• ????? ????? ?? ???? ?? 1-2 ??? ????.
• - ????????????????? 3-4 ??' ????.
• ???? ?????? ?????? 1-2 ??? ????.
• ???? ????? 2-3 ??? ????.
• ?????? 2 ??' ????.

42
????? ????

• ?????? ????? 2 ???? ??/??? ????? ??????.
• ????????
• ????? ????, ??? ??????, ???? ???.
• ????? ?????
• 2 ?????? ???? ????

43
????? 3 ??? ???, ??? ??? ???? ???