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BCMB

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Mechanisms of proton transfer -Mechanisms of ... And Proton Transfer. Rule #1, In most cases, especially for complex ... Coupled Proton/Electron transfer ... – PowerPoint PPT presentation

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Title: BCMB


1
BCMB 8110 Control of Electron Transfer
in Biology 1- Key Concepts -Transfer
Potentials -Electron transfer cofactors 2-
Overview of the electron transport
chain -Complex I -Complex II -Complex
III -Complex IV 3- Advanced Concepts in
Protein Structure/Function -Mechanisms of
redox control -Mechanisms of proton
transfer -Mechanisms of electron transfer
2
Transfer Potential and the Meaning of Life
Its all about energy!
3
Free Energy and Reduction Potential
4
Transfer Potential
5
Electron Carriers Coenzyme Q
6
Electron Carriers Iron Sulfur Clusters
7
Universal, Mobile Electron Carriers Ferredoxins
8
Electron Carriers Low Potential Ferredoxins
9
Electron Carriers Rieske Type Iron Sulfur
Clusters
10
Electron Carriers Cytochromes
11
Electron Carriers Cytochromes
12
Electron Carriers Blue Copper Proteins
13
Electron Carriers Flavoprotein
14
Electron Storage in Flavins
15
Complex III
16
Cytochrome bc1 Complex (Cont.)
17
Cytochrome bc1 Complex (Cont.)
18
Cytochrome bc1 Complex (Cont.)
19
Controlling Reduction Potentials,
ElectronTransfer And Proton Transfer
Rule 1, In most cases, especially for complex
metallocenters, proton and electron transfer are
coupled.
20
Redox Control Rubredoxin
21
Redox Control Rubredoxin
22
Redox Control Rubredoxin
23
Redox Control Rubredoxin
24
Redox Control Rubredoxin
25
Redox Control Rubredoxin
26
Redox Control Rubredoxin
27
Redox Control Nitrogenase
28
Redox Control Nitrogenase
29
Redox Control Nitrogenase
30
Redox Control Nitrogenase
31
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32
Redox Control Nitrogenase
33
2/1
pH-dependence for the P Redox Couple
34
Model for P-Cluster Redox and Proton Transfer
Reactions
Em1
Em2
P2
P1
PN
lt -348 mV
pKa
pKa
pKa
gt 8.5
gt 8.5
lt 6.0
Em2H
Em1H
P1(H)
P2(H)
PN (H)
gt -224 mV
-310 mV
35
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36
e-
H
8 H 8e- N2
e-
2 NH3 H2
37
Cytochrome Oxidase- Proton Transfer
38
Coupled Proton/Electron transfer
Cytochrome Oxidase
39
Coupled Proton/Electron transfer
Cytochrome Oxidase
40
Coupled Proton/Electron transfer
Cytochrome Oxidase
41
Coupled Proton/Electron transfer
Cytochrome Oxidase
42
Coupled Proton/Electron transfer
Cytochrome Oxidase
COX Cyc c broken beef heart mitochondria.
Capitanio et al. Biochemistry 42(16) p.4607-4612
43
Coupled Proton/Electron transfer
Cytochrome Oxidase
44
Electron Transfer Theory and Experiment
45
Electron Transfer Theory and Experiment
46
Electron Transfer Theory and Experiment
47
Electron Transfer Theory and Experiment
48
Electron Transfer Theory and Experiment
49
Electron Transfer Theory and Experiment
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