Layer-Specific Attentional Modulation in Early Visual Areas

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Layer-Specific Attentional Modulation in Early
Visual Areas
Elizabeth A. Buffalo Laboratory of
Neuropsychology National Institute of Mental
Health, NIH
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Attentional Modulation in Area V4
Fries, Reynolds, Rorie, and Desimone (Science,
2001)
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V4
Unattended stimulus
v2
v2
Attended stimulus
pp
V2
V4
V1
TEO
TE
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Spatial Attention Task
Response/Reward
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1

1

1

fix
RF
RF
RF
RF
0.5-5.0s
1.0s
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(No Transcript)
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Electrode Path
Modified from Gegenfurtner, Kiper, and Levitt
(1997)
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Superficial Recording
Deep Recording
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Electrode Path
Modified from Gegenfurtner, Kiper, and Levitt
(1997)
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Attentional Modulation in Area V2 Superficial
Layers
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Attentional Modulation in Area V2 Deep Layers
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Area V1
Area V2
Superficial Layers
Deep Layers
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Superficial Layers
Deep Layers
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Cortical Circuitry
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Cortical Circuitry
Feedforward intracortical connections V1 (II/III)
to V2 (IV)
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Cortical Circuitry
Feedforward intracortical connections V1 (II/III)
to V2 (IV)
Feedback intracortical and subcortical
connections V2 (VI) to V1 (VI) V1 (V) to SC, V1
(VI) to LGN, V2 (V) to SC, Pons, Striatum
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Superficial Layers Gamma-frequency
synchronization Attention
V2
pfc
V4
V1
TEO
TE
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Superficial Layers Gamma-frequency
synchronization Attention
Deep Layers Beta-frequency synchronization ???
V2
pfc
V2
pfc
V1
V4
V1
TEO
TEO
TE
TE
Superior Colliculus, Striatum, Pons, LGN
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Beta-frequency Oscillations
Baker, Kilner, Pinches, and Lemon (1999)
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Synchronization correlated with behavioral
response
Superficial Layers
Deep Layers
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Synchronization correlated with behavioral
response
Superficial Layers
Deep Layers
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Superficial Layers Gamma-frequency
synchronization Attention
Deep Layers Beta-frequency synchronization Motor
response inhibition?
V2
pfc
V2
pfc
V1
V4
V1
TEO
TEO
TE
TE
Superior Colliculus, Striatum, Pons, LGN
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Superficial Layers Coherence Across Time
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Deep Layers Coherence Across Time
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Cortical Circuitry
Higher Cortical Areas
LGN
SC
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Cortical Circuitry
Higher Cortical Areas
Inhibitory Interneurons
LGN
SC
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Collaborators
Robert Desimone Pascal Fries Tim Buschman David
Heister Partha Mitra