NANOTHERAPEUTICS: FROM BENCH TO BEDSITE

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NANOTHERAPEUTICSFROM BENCH TO BEDSITE
UNIVERSITY OF MARYLAND CENTER FOR NANOMEDICINE
AND CELLULAR DELIVERY
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What is nanomedicine?

• Nanobiotechnology Convergence of nanotechnology
  with modern biology
• Nanomedicine The use of nanobiotechnology in
  medicine
• Imaging agents and diagnostics
• Real-time assessment to accelerate clinical
  translation
• Multifunctional, targeted devices
• Monitoring predictive molecular changes
• Research enablers chip-based nanolabs
• Etc.

http//nano.cancer.gov/

Center for Nanomedicine Cellular Delivery
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University of Maryland Center for Nanomedicine
Cellular Delivery

• Established in March 2005
• Emphasis on targeted delivery of bioactive agents
  (drugs, imaging agents, genes, etc.)
• 26 faculty members from 3 campuses
• Engineering, Chemistry, Pharmacy, Medicine,
  Dentistry and Law
• Expertise
• Nanocarrier engineering and characterization
• Targeted delivery and transport
• Translational capabilities
• Regulatory aspects
• Strategic Partnerships
• Maryland NanoCenter (UMCP)
• University of Maryland Greenebaum Cancer Center
• Key attribute Integration of expertise in
  nanoengineering, drug delivery and clinical
  translational research

Center for Nanomedicine Cellular Delivery
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Cancer Nanotherapeutics
The real estate analogy of success in drug
delivery is location, location, location EA
Sausville, J Clinical Oncology 22 1535 (2004)
Pharmacy, Radiology and Greenebaum Cancer Center
Collaboration Supported by American Russian
Cancer Alliance, NIH (NIBIB) Advanced Nuclide
Technologies (Patent Pending)
Center for Nanomedicine Cellular Delivery
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The Nanopill

• How can we design nanocarriers for oral drug
  delivery?

Internalization
MRI-Arthiritis
UMB-Harvard
Long term benefit to patients Taking an oral
tablet or suspension, yet targeting to the site
of action
Center for Nanomedicine Cellular Delivery
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Promise of Nano as Gene Medicine

• Pieces of DNA (or RNA,) are quickly broken down
  in blood stream
• Nano complexes can protect and deliver to site of
  action

Transfection
UMB-UPENN
Reaping the benefits of human genome project for
treating patients Patent pending-Funded by NIH
(NCI)
Center for Nanomedicine Cellular Delivery
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New Nanoconstructs Critical role of Engineering
and Chemistry
Center for Nanomedicine Cellular Delivery
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Critical Role of Translation to Clinic
Regulatory / FDA
The sum is much greater than one-Nanomedicine by
necessity is collaborative and transcends
departments and institutions
Center for Nanomedicine Cellular Delivery
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Maryland NanoBiotech
UMB Nanomedicine Diagnosis Therapy
Molecular Bioprocessing
Nanotherapeutics
UMBI Biotechnology Components Bioprocessing GMP/Sh
ady Grove
UMCP Systems Engineering Biosensors BioMEMS

• Joint Appointments
• Seed Funding
• Technical Support

• Research
• Workforce development
• Entrepreneurial

Nanofabrication
Thanks to Support by DBED and USM
Center for Nanomedicine Cellular Delivery
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Maryland Nanomedicine Alliance?
JHU Institute for NanoBiotechnology Nanotherapeuti
cs
Nanomed Companies Assoc for Nanobiotech
USM Maryland NanoBiotech Nanomedicine
Federal NIST, NIH, NCL, FDA
State DBED,
TEDCO Other???
Sharing resources to strengthen Marylands
standing in nanomedicine research, development
and commercialization
Center for Nanomedicine Cellular Delivery
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Acknowledgement
MEMBERS OF CENTER FOR NANOMEDICINE AND CELLULAR
DELIVERY AND PARTNERS http//www.pharmacy.umaryla
nd.edu/nanomedicine
To Learn More About Nanomedicine Visit us on
NANOMEDICINE RESEARCH DAY March 23, 2007 at UMB