Gene Regulation

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??????????????????????? (Gene Regulation)
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Nuclear transplantation
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a2b2 a2d2 a2g2 a2e2

• Hemoglobin A
• Hemoglobin A2
• Hemoglobin F
• Embryonic-Gower Hemoglobin

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Enzyme
??????????????? 2 ????

• Constitutive enzyme ????????????????????????
  - enz. ??????????? glycolysis ???????
• Adaptive enzyme ????????????????????????????????
  ???? - b-galactosidase ???????

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Operon
Escherichia coli
Jacob and Monod
Operon theory
??????????
Operon

• ???????????? (structural gene) -
  ????????????????????????????????????????? ????
  ???????
• ??????????????????? (operator site)
  ??????????????????????????????????????
  ???????????????

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Repressor protein
???????????????????????????? ???????????????????
?????????????????????????????? ???????????????????
RNA polymerase ????????????????????????
????????????????? ????????????? mRNA
?????????????????? ??????????????????????????????
? RNA polymerase ????????????????????
?????????????????????????? mRNA ??????????????????
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Repressor protein
Regulator gene
transcription
mRNA
translation
Repressor protein
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lac-operon
????? repressor protein
Regulatary gene Operator site Promotor
site Structural gene
?????????? RNA polymerase ?????
???????????????????????????????repressor protein

• ??? Y ???????????? galactoside permease
• ???A???????????? galactoside transacetylase
• ??? Z ????????????b-galactosidase

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