Pr

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Prípad SD IAP c. 262
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Klinické údaje

• 76-rocný muž sledovaný pre tumor mocového
  mechúra, na CT zachytený tumor pravej oblicky
  priemeru 4 cm
• makro sivocervený, dobre ohranicený, s drobnými
  dutinkami, subkapsulárny

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CK 7
RCC
Vimentin
EMA
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Racemáza P504S
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Imunohistochémia

• pozit. EMA, M903, Vimentin (fokálne)P504S, AE
  1/3
• negat. CD-10, RCC, SMA, Dezmín, HMB-45, CEA,
  CK7

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Mucinous tubular and spindle cell carcinoma.
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História

• Ordonez (1996), Loreta (1998), He (1998), Otani
  (2001) neklasifikovaný
• Parwani (2001) LG myxoid renal epithelial
  neoplasm
• Hes (2002), Razoky (2002)
• WHO 2004

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• LG polymorfný renálny tumor mucinózny,
  tubulárny, spindle cell
• 17 82 rokov
• M / Ž 1 / 4
• v minulosti neklasifikovaný alebo sarkomatoidný

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Genetika

• WHO
• losses 1,4,6,8,13,14
• gains 7,11,16,17
• ???

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Histogenéza

• distálny nefrón, Henleho klucka
• proximálny nefrón, vztah k papilárnemu Ca
• ?

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Dif. dg.

• metanefrický adenóm
• onkocytóm
• LG Bellini
• konvencný RCC
• papilárny RCC
• sarkomatoidný RCC
• juxtaglomerular cell tumor
• angiomyolipóm

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Použitá literatúra

• WHO 2004
• Expanding the Histologic Spectrum of Mucinous
  Tubular and Spindle Cell Carcinoma of the Kidney.
  Samson W. Fine, MD Pedram Argani, MD Angelo M.
  DeMarzo, MD, PhD Brett Delahunt, MD Thomas J.
  Sebo, MD Victor E. Reuter, MD Jonathan I.
  Epstein, MD, American Journal of Surgical
  Pathology. 30(12)1554-1560, December 2006.
• Review of mucinous tubular and spindle-cell
  carcinoma of the kidney with a focus on clinical
  and pathobiological aspects, N. Kuroda, M. Toi1,
  M. Hiroi, T. Shuin and H. Enzan, Histopathol 20,
  221-224 (2005)
• Low-grade myxoid renal epithelial neoplasms with
  distal nephron differentiation, A. Parwani, Human
  Pathology, Volume 32, Issue 5, Pages 506-512
• Mucinous tubular and spindle cell carcinoma of
  kidney is probably a variant of papillary renal
  cell carcinoma with spindle cell features. Shen
  SS, Ro JY, Tamboli P, Truong LD, Zhai Q, Jung SJ,
  Tibbs RG, Ordonez NG, Ayala AG, Annals of
  diagnostic pathology 11 (2007) 13 - 21