Tolllike receptors

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Toll-like receptors Originally indentified in
Drosophila Binds to LPS Identified in mice by
Bruce Beutler
Similar to domain on the IL-1 receptor
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In neutrophils and macrophages
These act as antimicrobials
Inducible nitric oxide synthetase (iNOS)
Induced by receptors suchas TLRs or exposure to
cytokines by phagocytes L-arg O2 NADPH ?
NO L-citrulline NADP
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Signal Transduction
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VL
VH
Complex pulled apart to see complementary
surfaces
Flu antigen
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HIV Protease in its Ab binding pocket
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Unbound Antibody
Antibody bound to antigen
Conformational Change upon binding Ag
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SC 5 Ig Like domains S-S_ to Fc
receptor Proteolytically cleaved
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