Figure 1. HIV-1 Integrase: A New Drug Target

1
Entry
Reverse transcription
HIV dsDNA
HIV ssRNA genome
Integration
Host genomic DNA
Figure 1. HIV-1 Integrase A New Drug Target For
entry HIV binds to receptors (CD4 blue and CCR5
or CXCR4 green) and releases viral
single-stranded RNA genome that is subsequently
reverse transcribed to double-stranded DNA.
Elvitegravir inhibits integrase that mediates an
essential step, integration of HIV dsDNA into
host genomic DNA.