Carboxylic acid derivatives Chapter 18

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Carboxylic acid derivativesChapter 18

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Outline 1. Classification and nomenclature of
carboxylic acid derivatives 2. Structure of
carboxylic acid derivatives 3. Reactions of
carboxylic acid derivatives with nucleophiles 4.
Hydrolysis of carboxylic acid derivatives 5.
Reduction of carboxylic acid derivatives 6.
Synthesis of carboxylic acid derivatives 7.
Condensation polymers
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Outline 1. Classification and nomenclature of
carboxylic acid derivatives 2. Structure of
carboxylic acid derivatives 3. Reactions of
carboxylic acid derivatives with nucleophiles 4.
Hydrolysis of carboxylic acid derivatives 5.
Reduction of carboxylic acid derivatives 6.
Synthesis of carboxylic acid derivatives 7.
Condensation polymers
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More examples
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Outline 1. Classification and nomenclature of
carboxylic acid derivatives 2. Structure of
carboxylic acid derivatives 3. Reactions of
carboxylic acid derivatives with nucleophiles 4.
Hydrolysis of carboxylic acid derivatives 5.
Reduction of carboxylic acid derivatives 6.
Synthesis of carboxylic acid derivatives 7.
Condensation polymers
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Reactivity with nucleophiles is decreased by the
stabilizing conjugation, which depends on the
electron donating ability of X Acid
chlorides gt anhydrides gt esters, acids gt amides gt
nitriles gt salts
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Outline 1. Classification and nomenclature of
carboxylic acid derivatives 2. Structure of
carboxylic acid derivatives 3. Reactions of
carboxylic acid derivatives with nucleophiles 4.
Hydrolysis of carboxylic acid derivatives 5.
Reduction of carboxylic acid derivatives 6.
Synthesis of carboxylic acid derivatives 7.
Condensation polymers
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3. Reactions of carboxylic acid derivatives with
nucleophiles
Reactions of acid chlorides
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Reactions of anhydrides
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Reactions of esters
Alkaline hydrolysis of esters
4. Hydrolysis of carboxylic acid derivatives
Acid-catalyzed hydrolysis of esters is the
reaction of esterification, going backwards.
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5. Reduction of carboxylic acid derivatives
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Reaction of esters with Grignard reagent
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6. Synthesis of carboxylic acid derivatives
Beckmann Rearrangement
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Outline 1. Classification and nomenclature of
carboxylic acid derivatives 2. Structure of
carboxylic acid derivatives 3. Reactions of
carboxylic acid derivatives with nucleophiles 4.
Hydrolysis of carboxylic acid derivatives 5.
Reduction of carboxylic acid derivatives 6.
Synthesis of carboxylic acid derivatives 7.
Condensation polymers
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