Product Development

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LifePak, MarineOmega BioPhotonic Scanner
Carsten R. Smidt, Ph.D., FACN Vice President,
Global RD, Pharmanex
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What is LifePak?

• A comprehensive nutritional wellness program
  delivering the optimum amounts of all essential
  and generally beneficial nutrients for long-term
  health and well-being.

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LifePak Health Support Benefits

• Optimum supplementation for general well-being
• 1. Addresses nutrient deficiencies
• 2. Cardiovascular benefits
• 3. Complete bone nutrition
• 4. Promotes healthy immune function
• 5. Supports blood sugar metabolism
• 6. Protects against the symptoms of aging
• 7. Raises your antioxidant defense

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7. Antioxidant Health Support Benefits
Journal of the American Medical Association June
2002
low levels of the antioxidant vitamins
(vitamins A, E, and C) may increase risk for
several chronic diseases. Most people do not
consume an optimal amount of all vitamins by diet
alone. It appears prudent for all adults to
take vitamin supplements.
Robert H. Fletcher, MD, MSc Kathleen M.
Fairfield, MD, DrPH, Harvard UniversityJournal
of the American Medical Association 2002 287
3127-3129
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Free Radicals Antioxidants

• Free Radicals
• Highly reactive, short-lived molecules
• Damage cells and genetic material (DNA)
• 70,000 free radical attacks on DNA every day in a
  cell
• Aging process
• Implicated in most health conditions
• Many different types of free radicals

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Sources of Free Radicals

• Metabolism in your mitochondria

• Environmental pollution (smog, ozone, NO2)
• Radiation exposure
• sunlight (UV-light), X-rays, etc.
• Smoking
• 10,000,000,000,000,000 free radicals/cigarette!

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Free Radicals Antioxidants

• Antioxidants fight free radicals
• Slow down aging process improve health
• over 30,000 research studies on antioxidant
  health benefits
• affecting over 50 health conditions,
  incl.cardiovascular function, eye health, CNS
  health, skin health, etc.
• Many antioxidants work together Antioxidant
  Defense System
• Relies on a steady supply of dietary antioxidants

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LifePak 40 Antioxidants

• All 8 forms of natural vitamin E 300 IU
• Buffered vitamin C 500 mg
• Selenium, Copper, Zinc, Manganese
• Carotenoids
• as found in 5-10 fruits vegetables per day
• Over 20 Flavonoids
• Green tea catechins, quercetin, naringenin,
  hesperidin, grape seed polyphenols
• Alpha-Lipoic Acid 30 mg

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Comprehensive Convenient

• Better than these 7 popular supplements together.

Multi Carotenes
Multi Vitamin
Vitamin E 300 IU
gt
Chromium 200 mcg
Calcium Magnesium
Vitamin C 500 mg
Multi Flavonoid
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LifePak Science

• First to show antioxidant and cardiovascular
  benefits in double-blind studies
• 200,000 published studies on LifePaks
  antioxidants
• Nearly 800,000 published studies on all LifePak
  ingredients
• LifePak is built on scientific consensus!

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LifePak Clinical StudyAntioxidant and
Cardiovascular Health
Beta-carotene
LDL Protection
Vitamin E
Smidt CR, Seidehamel RJ, Devaraj S, Jialal I.
FASEB Journal Vol.13 No.4, p.A546, March 1999.
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LifePak Antioxidant Capacity (ORAC)Jan 2003
Recommended daily antioxidant intake (R. Prior,
USDA)
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Pharmanex BioPhotonic Scanner See YOUR
antioxidant score in 3 minutes!

• Measures your personal antioxidant protection
  (skin carotenoids).
• Measure antioxidant effect of LifePak in your own
  body!
• Easy non-invasive.
• Scientifically and clinically validated.

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Pharmanex BioPhotonic Scanner

• Invented by Werner Gellermann, Ph.D. (U. Utah)
• Patent rights licensed to Pharmanex
• Measures carotenoid antioxidants in skin
• important group of antioxidants
• part of the antioxidant defense system in the
  body
• good indicator of your carotenoid antioxidant
  status
• Highly specific for carotenoids
• Based on Raman spectroscopy

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What is Raman Spectroscopy?
Raman effect Intense monochromatic light (one
color only) interacts with molecules that have
vibrational energy (e.g., carotenoids) and gets
scattered at a higher wavelength (color). Sir C.
V. Raman, Nobel Prize in Physics, 1930
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Accepted by the Scientific Community

• New York Academy of Sciences, Feb 2003
• Oxygen Club of California, Feb 2003 and Feb 2004
• FASEB/American Society of Nutritional Sciences -
  April 2003 and April 2004
• Gordon Research Conference, Jan 2004
• Review paper published in Current Topics in
  Nutraceutical Research, May 2004
• American College of Nutrition, October 2004

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Demographic Study - Sep 2002

• 1,375 Subjects Results show that Skin Carotenoid
  Signal
• Is not influenced by Age, gender or skin
  pigmentation (race/ethnicity)
• Is high in people who eat more fruits
  vegetables
• Is high in people who take LifePak
• Is low in people who smoke or have oxidative
  stress (free radical damage)

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2004 Data Histogram
Mean 25,406 32,948 Subjects
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2004 Data Fruits Vegetables
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2004 Data LifePak Usage
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2004 Data Body Mass Index (BMI)
Overweight individuals and anyone on a diet
should increase antioxidant protection through
diet and supplementation.
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Clinical Study - Sep 2002 LifePak ? Scanner Score
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Carotenoid Correlation Study June 2004
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Published Review Paper

• Current Topics in Nutraceutical Research, May
  2004
• Peer-reviewed scientific journal
• Download at www.pharmanex.com gt Whats New link

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How Does Measuring Skin Carotenoids Predict
Antioxidant Status?
The Questions

• Carotenoids are the bodys first line of defense
  against free radicals.
• Carotenoid levels are most sensitive to
  oxidative stress

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The Antioxidant Network
NAD(P)
Carotenoids
THIOL cycle
NAD(P)H H
VITAMIN Ccycle
ROOH ROH
VITAMIN E cycle
Lipidwater interface
PUFA
O2 and other radicals
Metabolism, strenuous exercise, cigarette smoke,
pollution
Carotenoids
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Carotenoids Predict Antioxidant Status

• Recent paper published in the Journal of
  Nutrition, 2004
• Carotenoids (blood) are indicator of total
  antioxidant status
• Carotenoids interact with the antioxidant network
• Vitamin E (blood) is not a good indicator of
  antioxidant status

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Skin Carotenoid Scores

• Example of a person reading 25,000
• RED 19,000 and less Poor diets, no/ineffective
  supplements, genetic factors, or smoking.
• YELLOW 20,000 - 29,000 Better diets and/or
  supplements.
• GREEN 30,000 - 39,000 Healthy diets rich in
  fruits vegetables and/or good supplements.
• BLUE 40,000 Excellent diets high in fruits
  vegetables and excellent supplements.

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What Does 25,000 Mean?
The Questions

• Serum equivalent 1.5 mcg/ml
• 2-3 fruits/veg./day
• Average diet
• NOT VERY GOOD

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LifePak Essentials SuperAntioxidant

Available in Denmark, Norway, France, Spain
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MarineOmega

• Everybody needs more omega-3 fatty acids.
• New MarineOmega is the best omega-3 supplement.

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Fatty Acid Metabolism
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Fatty Acid Metabolism
Omega-3 (Plant)
Omega-3 (Marine)
EPA
DHA
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?-Linolenic Acid
Triglycerides Cardiac Rhythm Brain Function
Anti-inflammatory Eicosanoids, 3-PG
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Humans evolved with optimum 11 ratio of ?-6
?-3 fatty acids
Today, we eat 20 times more omega-6 than omega-3
fatty acids!
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Scientific Substantiation

• Over 100,000 published scientific studies on
  health benefits of fish and fish oil (Medline
  1966-2004)

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Recommendations

• US National Academy of Sciences, Institute of
  Medicine, (1999) Food and Nutrition Board
  recommends
• 650 mg EPA DHA daily
• min. 220 mg EPA/day
• min. 220 mg DHA/day
• min 300 mg DHA/day for pregnant and lactating
  women
• Typical US intake is only 100-200 mg/day EPA
  DHA

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Dietary Sources of Omega-3
Marine sources (EPA DHA)Salmon, Tuna,
SardinesHerring, Mackerel Plant sources
(LNA) (weak biological efficacy) Green leafy
vegetablesFlaxseed oilCanola oil
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Fish Can Be Fishy!

• Not everyone likes to eat fish
• Freshness
• Contamination
• Fish is by far the number-1 dietary source for
  contaminant exposure
• heavy metals (methyl-Hg)
• chlordane (67)
• dioxins (64)
• PCBs (60)
• DDT (freshwater fish 75)
• (Dougherty et al., Environ.Res.Sec.A84170, 2000)

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MarineOmega Is Guaranteed Clean!

• Pharmanex tests MarineOmega for
• Heavy metals (Hg, Cd, Pb, Cr) As less than 100
  ppb
• Pesticides
• DDT, DDD, DDE, HCB, Lindane each less than 50
  ppb
• PCBs less than 90 ppb
• 25 Dioxins and Furans less than 2 ppt total
• p-Anisidine Value, Acid Value, Iodine Value, Free
  Fatty Acids, Peroxide Value, Cold Test
• Cholesterol (lt 4 mg/g)
• Complete Fatty Acid Profile
• Microbiological Testing

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Krill Oil

• Krill (Euphausia superba)
• Zooplankton (gt 60 mm long)
• from Antarctic Ocean
• Most abundant biomass (lt 1 harvested)

• Krill Oils Unique Features
• High in phospholipids (40)
• Rich in bioactive EPA and DHA
• Contains potent antioxidants

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Krill Oil High-Activity EPA DHA

• Uniquely efficacious EPA and DHA
• Highly bioavailable phospholipid form
• In unique chemical structure (sn-2) for maximum
  efficacy
• cell membranes
• cardiovascular function
• brain nerve function
• Natural Structured Lipid

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Krill Oil Antioxidant Capacity

• Exceptionally high ORAC value
• Astaxanthin (Carotenoid)
• Unique Flavonoids

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Health Support Benefits

• provides pure and highly effective omega-3 fatty
  acids
• helps balance your fatty acid nutrition (?-6
  ?-3 ratio)
• helps balance your normal inflammatory response
• joint cartilage health skin health
• promotes healthy heart function
• helps maintain normal blood triglyceride levels
• promotes normal heart rhythm
• helps protect blood vessels
• essential for nervous system and brain function
• helps alleviate the physical and emotional
  symptoms of PMS
• improves antioxidant defense (Krill astaxanthin
  flavonoids)
• USAGE 2-4 Softgels/day (600-1,200 mg ?-3
  100-200 mg krill oil)

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LifePak MarineOmega

• The Synergistic Combination
• LifePak MarineOmega Foundation
• comprehensive anti-aging benefits
• enhances absorption of LifePak
• astaxanthin enhances BioPhotonic scanner score

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Recent Study in Am. J. Clin. Nutr.
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• Make sure all your meals contain antioxidants
  phytonutrients!
• Take LifePak MarineOmega with your two main
  meals!
• Include fruits vegetables into your other
  meal(s) and snacks!

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LifePak MarineOmega(for illustration purposes
only--not based on an actual study)


Meal
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Live Better, Longer
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