Anterior Pituitary

1
Anterior Pituitary

• Lindsey.elmore_at_ucsf.edu

2
Be able to match each hypothalamic hormone with
the anterior pituitary hormone it regulates and
tell whether the action of the regulator is
stimulatory or inhibitory.
3
Know the clinically available drugs related to
the hypothalamic and anterior pituitary and their
possible uses.

• Somatostatin anti-growth hormone
• Octreotide used to treat acromegalia, esophageal
  varicies, diarrhea
• Shorter sequence structure and shorter di-sulfide
  bond
• Thyrotropin releasing hormone
• Protirelinuseful for diagnostic purposes
• GnRH
• Leuprolide and other congeners palliative for
  prostate CA, treats endometriosis, in vitro
  fertilization, breast CA, anemia 2/2 leiomyoma
• Recombinant GH
• Somatropin dwarfism, GH deficieny

4
Know the clinically available drugs related to
the hypothalamic and anterior pituitary and their
possible uses.

• GHRH
• Sermorelin
• IGF-1
• Mecasermin
• PRL release inhibitors
• Bromocriptine, pergolide, and cabergoline
  acromegaly, in vitro fertilization,
  hyperprolactinemia, Parkinsons disease,
  prolactinoma
• ACTH
• Cosyntropin infantile spasms, diagnosis

5
Be able to recognize the role of peptide
modifications at the termini of TRH.

• Lactam and amide on the end of molecule protects
  it from degradation.

6
For GnRH, know the function and modifications
used to provide more potent agonists.
Hydrophobic pocket
7
Describe the POMC family.
400 AAs containing ACTH, endogenous opiods, and
MSH.