Pharmacology 4

1
Pharmacology 4

• Control of Inflammation
• NSAIDs

2
Chemical Mediators of Inflammation

• Include
• vasoactive amines eg histamine and serotonin
• neuropeptides
• plasma proteases
• arachidonic acid metabolites ie prostaglandins,
  leukotrienes and lipoxins

3
Arachidonic Acid (AA)metabolites

• Collectively called eicosanoids
• Act like short-acting, local hormones
• Have roles in almost all parts of inflammatory
  process
• AA is a component of cell membrane phospholipids,
  metabolised by phospholipase
• Two main metabolic pathways, 1 results in
  prostaglandins, 2 in leukotrienes

4
Reduction of Inflammation

• Blocking phospholipase (corticosteroids see next
  lecture)
• Blocking the prostaglandin pathway
• Note there are 2 forms of cyclo-oxygenase (COX1
  and 2), which is the key enzyme involved in PG
  synthesis.
• COX 1 is found in gastric mucosa where it is
  important in maintaining stomach mucosal
  defences. It also occurs in most other tissues
• COX 2, discovered in 1990, found in synovial
  cells and macrophages

5
(No Transcript)
6
(No Transcript)
7
(No Transcript)
8
(No Transcript)
9
(No Transcript)
10
(No Transcript)