Proteinnucleic acid interaction mapping

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BCM RESEARCH-IBI SEMINAR SERIES
Protein-nucleic acid interaction mapping
Timothy R. Hughes Professor Banting and Best
Department of Medical Research Department of
Molecular Genetics Terrence Donnelly Centre for
Cellular and Biomolecular Research University of
Toronto Friday April 24, 2009 1200
Noon Biological Sciences 211 University of
Calgary Host Gordon Chua
Abstract One of the major impediments to our
understanding of genome function is lack of
accurate and complete knowledge of how proteins
interact with nucleic acid. Recent technical
advances now make it possible to assay relative
preference of proteins for tens of thousands of
distinct sequences in vitro, thus removing
confounding variables at work in vivo. We are
attempting to catalogue descriptions of protein
interactions with DNA and RNA in vitro on a
genomic scale. We anticipate that these data will
be invaluable in formulating models that explain
how cells recognize genomic features, how gene
regulatory networks are organized, and how
genomes evolve.
Pizza and pop will be provided