Reengineering Adeno-Associated Virus (AAV)

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Junghae Suh, Ph.D. Assistant Professor Dept. of
Bioengineering Rice
Reengineering Adeno-Associated Virus (AAV)
Genetically encoded nanoparticle
Barriers to delivery

• High efficiency in human cells
• No known pathology
• Highly monodisperse
• Control properties through genetic engineering

• Particle tracking
• Obtain x, y positional data over t
• Mean-Square Displacement (MSD), Diffusivity,
  Velocity, Modes of Transport

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Virus-based Imaging Agents
Junghae Suh, Ph.D. Assistant Professor Dept. of
Bioengineering Rice

• Biomedical Imaging
• Problem Need enhanced contrast with improved
  targeting for early detection
• Our solution Virus-based contrast agents with
  high selectivity to target cells
• Extracellular barriers to delivery

Exploit unique properties of viruses for
nanomedicine