Welcome Each of You to My Molecular Biology Class

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Welcome Each of You to My Molecular Biology Class
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Molecular Biology of the Gene, 5/E --- Watson et
al. (2004)
Part I Chemistry and Genetics Part II
Maintenance of the Genome Part III Expression
of the Genome Part IV Regulation Part V Methods
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Part II Maintenance of the Genome
Dedicated to the structure of DNA and the
processes that propagate, maintain and alter it
from one cell generation to the next
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Ch 6 The structures of DNA and RNA Ch 7
Chromosomes, chromatins and the nucleosome Ch 8
The replication of DNA Ch 9 The mutability and
repair of DNA Ch 10 Homologous recombination at
the molecular level Ch 11 Site-specific
recombination and transposition of DNA
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• Molecular Biology Course

• CHAPTER 10 Homologous recombination at the
  molecular level

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• All DNA is recombinant DNA.
• Genetic exchange works constantly to blend and
  rearrange chromosomes, most obviously during
  meiosis, when homologous chromosomes pair prior
  to the first nuclear division.
• During this pairing, genetic exchange between the
  chromosomes occurs. This exchange, classically
  termed crossing over, is one of the results of
  homologous recombination.

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OUTLINE

1. Models for Homologous Recombination (two
   models)
2. Homologous Recombination Protein Machines (RecBCD
   pathway)
3. Homologous Recombination in Eukaryotes (meiosis
   recombination, proteins)
4. Mating-Type Switching (a gene conversion event)
5. Genetic Consequences of the Mechanism of
   Homologous Recombination (exchange or conversion)
   

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CHAPTER 10 Homologous recombination at the
molecular level
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Topics 1 2 are the keys to understand
homologous recombination and other topics.
Completely understand two animations on your CD
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CHAPTER 9 The mutability and repair of DNA
Homework
Review your textbook