Hepatitis E - Clinical Features - PowerPoint PPT Presentation

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Hepatitis E - Clinical Features

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Hepatitis E - Clinical Features. Incubation period: Average 40 days. Range 15-60 days ... Outbreaks or Confirmed Infection in 25% of Sporadic Non-ABC Hepatitis ... – PowerPoint PPT presentation

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Title: Hepatitis E - Clinical Features


1
Hepatitis E - Clinical Features
  • Incubation period Average 40 days
  • Range 15-60 days
  • Case-fatality rate Overall, 1-3 Pregnant
    women, 15-25
  • Illness severity Increased with age
  • Chronic sequelae None identified

2
Hepatitis E Virus Infection
Typical Serologic Course
Symptoms
ALT
IgG anti-HEV
IgM anti-HEV
Titer
Virus in stool
0
1
2
3
4
5
6
7
8
9
10
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13
Weeks after Exposure
3
Hepatitis E - Epidemiologic Features
  • Most outbreaks associated withfecally
    contaminated drinking water
  • Minimal person-to-person transmission
  • U.S. cases usually have history of travelto
    HEV-endemic areas

4
Geographic Distribution of Hepatitis E
Outbreaks or Confirmed Infection in gt25 of
Sporadic Non-ABC Hepatitis
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