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Williams, D, Lemke, T, Foye's Principles of Medicinal Chemistry, 5th edition. ... One important consideration when evaluating potential effects of DHEA ... – PowerPoint PPT presentation

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Title: http:www'emedicine'comPEDtopic1051'htm


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  • http//www.emedicine.com/PED/topic1051.htm
  • Serum Levels of Pregnenolone and
    17-hydroxypregnenolone in Patients withRheumatoid
    Arthritis and Systemic Lupus Erythematosus
    Relation to Other Adrenal Hormones Vogl, Falk,
    Dorner, Scholmerich, Straub, The Journal of
    Rheumatology 2003 302
  • Conversion of pregnenolone to DHEA by human 17
    alpha-hydroxylase/17,20-lyase(P450c17) Soucy,
    Luu-The, European Journal of Biochemistry, 2000
    267
  • Ingestion of a Dietary Supplement Containing
    Dehydroepiandrosterone (DHEA) and Androstenedione
    Has Minimal Effect on Immune Function in
    Middle-Aged Men Kohut, et al. JOunrla of the
    American College of Nutrition 2003 225
  • Williams, D, Lemke, T, Foyes Principles of
    Medicinal Chemistry, 5th edition. 2002
    Lippincott Williams and Wilkins
  • Tomova, A, Kumanov, P. Are dehydroepiandrosterone
    sulphate and lipids associated with erectile
    dysfunction? Maturitas 2004 50294-299
  • Feldman, H.A., et al. Age trends in the Level of
    Serum Testosterone and Other Hormones in
    Middle-Aged Men Longitudinal Results from the
    Massachusetts Male Aging Study. The Journal of
    Clinical Endocrinology Metabolism 2002 87(2)

DHEA is a native, cholesterol-derived androgen
precursor. The primary metabolic pathway is
shown in Figure (XX). Oral dietary supplements
have been shown to increase serum DHEA levels as
well as levels of downstream androgens (Kohut, et
al 2003). This increase in androgens is
foundation for the purported anti-aging,
improved immune response, increased libdo, etc.
of dietary supplements. Much of the interest and
hype regarding DHEA assumes that the lack of DHEA
causes many of the symptoms of aging (Feldman, et
al 2002). Much of the research has tested the
cause-and-effect relationships between DHEA and
the symptoms of aging. One important
consideration when evaluating potential effects
of DHEA supplements is that animal have limited
applicability to humans, as the sources of
androgens varies by species (Kohut, et al 2003).
The immune effects, although present in vitro and
in mice, were not exhibited in otherwise healthy
men (Kohut, et al 2003). Erectile dysfunction
was demonstrated to be unaffected by DHEA serum
levels and supplementation (Tomova, Kumanov
2004). The side effects of DHEA are similar to
androgen agonists and replacements, including the
development of the secondary sex characteristics
of the opposite gender (Williams, Lempke 2002).
Both genders may also experience electrolyte
retention (Williams, Lempke 2002).
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