DRUG DISCOVERY

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DRUG DISCOVERY

• Random Search
• e.g., buying paintbrush, mop, hammer, gluestick,
  nail, etc. etc.
• for hanging a picture frame on the wall
• Rational Design
• e.g., buying a nail for hanging the frame
• Combinatorial Search
• e.g., buying a box of nails of different sizes
  for hanging the frame

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WHY COMBINATORIAL CHEMISTRY?
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FULL TOOLBOX REQUIRED TO COMPETE
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GENERATING A COMBINATORIAL LIBRARY
? MIXTURE SYNTHESIS
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? SPATIALLY ADDRESSABLE SYNTHESIS
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? SPLIT AND MIX STRATEGY
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? SPLIT AND MIX STRATEGY
MIX and SPLIT
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? DECONVOLUTION BY TAGGING
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? DECONVOLUTION BY TAGGING (continued)
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? DECONVOLUTION BY ENCODED DNA