RASS Annual Business Meeting

1
RASS Annual Business Meeting Reception

• Monday, March 7, 2005
• 600 p.m. 730 p.m.
• New Orleans Convention Center Room 229

Laissez Le Bon Temps Rouler!
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Agenda

• Accomplishments for 2004-2005 (A. Jarabek)
• Status of RASS
• Introduction of new officers
• RASS Best Abstract Award (M. Gargas)
• RASS Best Student Abstract Award (M. Gargas)
• RASS Best Manuscript Awards (K. Krishnan)
• Advancing Risk Assessment
• Demonstrating Risk Assessment Application
• Web page revisions and logo contest (D. Proctor)
• Next Year Programs and Activities (K. Krishnan)
• Open Session for Membership Input
• Ideas to better serve RASS membership
• 2004 nomination of symposia workshops, continuing
  education, etc.
• Concluding comments by Incoming President (K.
  Krishnan)
• Panel Discussion Dose-dependent Transitions in
  Mechanisms of Toxicity

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Status of RASS 2005 Annual Meeting

• How many members belong 384 (? of 100)
• Budget (December 2004) 11,645
• Members registered to attend meeting as of March
  1 ??
• Additional revenue 4,900 (estimate)
• Annual meeting expenditure 2000 (estimate)
• Sponsored CE Courses 6
• Sponsored Symposia 6
• Secondary endorsements 26
• Precedent set with historical highlight Vinyl
  Chloride

4
RASS 2004-2005 Accomplishments

• Emphasize the role of specialty sections
• Monthly Telecon Series the State of our Science
• November NAS report on use of human studies
• December Dose-response assessment Past
  Present
• Rory Conolly, CIIT Centers for Health Research
• January Dose-response assessment Future
• Rory Conolly and Rusty Thomas, CIIT CHR
• February HESI Panel on Dose-dependent
  transition
• Coming yet this Spring
• April 13 Bruce Hope, OR DEP on bioterrorism
  risk assessment
• May 11 Michael Liebman, Windber Institute
  Discovery and Data mining in health care
• June 8 Woodrow Setzer, US EPA, NHEERL OP
  modeling
• Special thanks to Merck for generous offer of
  telecon system

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RASS 2004-2005 Accomplishments

• Updated RASS home page
• User friendly Information sharing
• Event broadcasting
• Logo contest
• Student membership and SAC liaison
• Letter soliciting student volunteer sent out
• Student to be determined ASAP for 2006
• Consider a Contemporary Concepts in Toxicology
  (CCT) workshop

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RASS 2005 CCT Workshop
Probabilistic Risk Assessment (PRA) Bridging
Components Along the Exposure-Dose-Response
Continuum
July 25 - 27, 2005 Omni Shoreham Hotel Washington
DC
Deadline for poster submission is May 12,
2005 For more information visit www.toxicology.org
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2005-2006 RASS Officers

• President Kannan Krishnan
• Vice President Mike Gargas
• Vice President-Elect Jennifer Orme-Zavaleta
• Secretary/Treasurer Lynne Haber
• Councilor (2 year) Teresa Leavens
• Councilor (1 year) Deborah Proctor
• Past President Annie Jarabek

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Outgoing Officers

• to Whom We Owe
• Many Thanks

• Councilor Lorenz Rhomberg
• Secretary/Treasurer Steve DiZio
• Past President Ed Sargent

Other Grande Gratitude to Jeanne Galbo CIIT
Centers for Health Research
9
RASS Best Abstract Competition

• 276 Abstracts with keyword risk assessment
  reviewed by chair of committee
• 137 Vetted by Awards Committee
• Scored based on criteria
• Originality
• Quality / Clarity
• Relevance to the risk assessor
• No vote for member with conflict of interest on
  any abstract

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RASS 2005 Best AbstractAwards Committee

• Mike Gargas, The Sapphire Group, Inc. (Chair)
• John Christopher, Cal EPA
• Michael Dourson, TERA, Inc.
• Annie Jarabek, CIIT CHR / US EPA

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RASS 2005Best AbstractTop Ten Blue Ribbon
Winners

• 377. A Framework/Approach for Incorporating PBPK
  Modeling into Cumulative Risk Assessment of
  Chemical Mixtures. R. Yang J. Dennison J.
  Lipscomb
• 381. Risk Assessment in Nephrotoxicology
  Sensitivity of Renal Tests. P. Potnis A.
  Maier T. Guidotti
• 402. Incorporation of Trichloroacetic Acid Plasma
  Binding in Human and Mouse in Trichloroethylene
  Risk Assessment. D. Keys M. Lumpkin J.
  Bruckner J. Fisher
• 404. Monte Carlo Analysis of Sources of
  Variability in Chloroform-induced Hepatic
  Cytolethality and Regenerative Proliferation in
  B6c3f1 Mice. Y. Tan R. Conolly
• 349. An integrated QSAR-PBPK model for simulating
  pharmacokinetics of chemicals in mixtures. K.
  Price K. Krishnan
• 847. A Harmonized PBPK Model for
  Trichloroethylene Risk Assessment. T. Covington
  H. Clewell J. Fisher D. Keys C. Hack J. Zhao

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RASS 2005Best AbstractTop Ten Blue Ribbon
Winners

• 866. Validation of a Human Physiologically-Based
  Pharmacokinetic Model for Vinyl Acetate Against
  Human Nasal Dosimetry Data. P. Hinderliter K.
  Thrall R. Corley L. Bloemen B. Matthew
• 1096. Assessment of neurotoxicity using zebrafish
  as a model organism. N. Roy C. Ton Y. Lin C.
  Parng
• 1304. A Mechanistic Model of Lifetime Cancer Risk
  for Inhalation Exposures to Reactive Gases. J.
  Kimbell D. Kalisak R. Conolly F. Miller A.
  Jarabek
• 1934. Evaluation of Systemic Toxicity in Mixtures
  of Trichloroethylene (TCE), Heptachlor (HEPT),
  and Di(2-ethylhexyl)phthalate (DEHP) Assessed in
  a 5x5x5 Design. J. Simmons S. Yeatts J. Zhao
  C. Gennings A. McDonald R. MacPhail
• 2110. Improved Dosimetric Adjustment Factors for
  Interspecies Extrapolation of Inhaled, Poorly
  Soluble Particles. B. Asgharian O. Price A.
  Jarabek F. Miller

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RASS 2005Best Abstract Award Winner

• Abstract 2110. (Thursday March 10)
• Improved Dosimetric Adjustment Factors for
  Interspecies Extrapolation of Inhaled, Poorly
  Soluble Particles.
• B. Asgharian, O. Price, A.M. Jarabek and F.J.
  Miller.
• CIIT Centers for Health Research

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RASS 2005 Best Student AbstractCompetition

• Submission process
• Student submits abstract and extended abstract
  (up to 5 pages)
• Advisor provides letter of recommendation
• Review process vetted by Award Committee based
  on criteria
• Originality
• Clarity
• Role of Student
• Special thanks to
• Taylor and Francis
• Burdock Group, Inc.

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RASS 2005 Best Student AbstractNominees

• 62. Decreased Acetaminophen and
  Bromobenzene-induced Hepatotoxicity and Lethality
  in Type 2 Diabetic Mice.   M. Mitra S. Sawant
  A. Dnyanmote J. Latendresse A. Warbritton H.
  Mehendale, University of Louisiana.
• 197. Rat Kidney injury molecule-1 (rKim-1) ELISA
  A sensitive assay for early detection of kidney
  tubular injury in preclinical toxicity studies.  
  V. Vaidya T. Ichimura J. Bonventre , Harvard
  Medical School, Brigham and Womens Hospital.
• 259. PBPK modeling of inter-child differences in
  pharmacokinetics on the basis of subject-specific
  data on hepatic CYP2E1 levels.   A. Nong D.
  McCarver R. Hines K. Krishnan, University of
  Montreal.
• 731. Role of Toxicokinetics in the
  Bioactivation-mediated Liver Injury of
  Thioacetamide in Ad Libitum Fed and Diet
  Restricted Rats.   J. Chilakapati M. Korrapati
  H. Mehendale, University of Louisiana.
• 2095. Characterization of Deltamethrin (Dlt)
  Metabolism in Adult Male Sprague-dawley Rats.  S.
  Anand W. Haines J. Bruckner J. Fisher S.
  Muralidhara D. Hunter S. Padilla, University of
  Georgia.

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RASS 2005 Best Student AbstractAward Committee

• Mike Gargas, The Sapphire Group, Inc. (Chair)
• Lisa Sweeney, The Sapphire Group, Inc.
• Jim McDougal, Wright State University
• James Holder, US EPA NCEA

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RASS 2005 Best Student AbstractWinner
Abstract 197. Rat Kidney injury molecule-1
(rKim-1) ELISA A sensitive assay for early
detection of kidney tubular injury in preclinical
toxicity studies. V. Vaidya, T. Ichimura, and
J. Bonventre Harvard Medical School, Brigham
and Womens Hospital.
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RASS Annual Best Manuscript Competition

• Nominations by membership
• Review of relevant journals published in past
  year
• Toxicological Sciences
• Toxicology Applied Pharmacology
• Human Ecological Risk Assessment
• Regulatory Toxicology Pharmacology
• Risk Analysis
• Chosen by Vice-President Awards Committee
• Top ten fully vetted
• Scoring criteria merit, clarity, and impact
• No vote on manuscript for committee member if any
  conflict of interest

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RASS 2005 AwardBest Manuscript Advancing Risk
Assessment Science
Awards Committee

• Kannan Krishnan, Univ. Montreal (Chair)
• Mel Andersen, CIIT CHR
• Marcy Banton, Lyondell
• Mike Gargas, The Sapphire Group, Inc.
• Annie Jarabek, CIIT CHR / US EPA
• William Slikker, NCTR

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2005 RASS Top Ten Papers ADVANCING SCIENCE OF
RISK ASSESSMENT

1. Ashani Y and Pistinner S. (2004). Estimation of
   the upper limit of human butrylchloinesterase
   dose required for protection against
   organophosphates toxicity a mathematically based
   toxicokinetic model. Toxicological Sciences 77
   358-367.
2. Conolly RB and Lutz WK. (2004). Nonmonotonic dose
   response relationships mechanics basis, kinetic
   modeling and implications for risk assessment.
   Toxicological Sciences 77 153-157.
3. Dorne JL, Walton K, Renwick AG. (2004). Human
   variability in the renal elimination of foreign
   compounds and renal excretion-related uncertainty
   factors for risk assessment. Food Chem. Toxicol.
   42(23) 275-98.
4. Englehardt JD (2004) Predictive Bayesian
   dose-response assessment for appraising absolute
   health risk from available information. Human
   and Ecological Risk Assessment 10 69-78.
5. Gaylor DW and Aylward LL. (2004). An evaluation
   of benchmark dose methodology for noncancer
   continuous data health effects in animals due to
   exposed to dioxin. Regulatory Toxicology and
   Pharmacology 40 9-17.

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2005 RASS Top Ten Papers ADVANCING SCIENCE OF
RISK ASSESSMENT

• 6. Gaylor DW, Lutz WK and Conolly RB. (2004).
  Statistical analysis of nonmonotonic
  dose-response relationships research design and
  analysis of nasal cell proliferation in rats
  exposed to formaldehyde. Toxicological Sciences
  77 158-164.
• 7. Toyoshiba H, Yamanaka T, Sone H, Parham FM,
  Walker NJ, Martinez J, Portier CJ. (2004). Gene
  interaction network suggests dioxin induces a
  significant linkage between aryl hydrocarbon
  receptor and retinoic acid receptor beta.
  Environ. Health Perspect. 112(12) 1217-24.
• 8. Razzaghi M and Kodell R. (2004) Quantitative
  risk assessment for developmental neurotoxic
  effects. Risk Analysis 24 1673.
• 9. Clark LH, Setzer RW and Barton HA. (2004)
  Framework for evaluation of physiologically-based
  pharmacokinetic models for use in safety or risk
  assessment. Risk Analysis 24 1697.
• 10. Calabrese EJ (2004). Hormesis from
  marginalization to mainstream a case for
  hormesis as the defaul dose-response model in
  risk assessment. Toxicol. Appl. Pharmacol. 197
  125-136.

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Risk Assessment Specialty Section 2005

• Best Paper Advancing the
• Science of
• Risk Assessment
• Toyoshiba H, Yamanaka T, Sone H, Parham FM,
  Walker NJ, Martinez J, Portier CJ. (2004). Gene
  interaction network suggests dioxin induces a
  significant linkage between aryl hydrocarbon
  receptor and retinoic acid receptor beta.
  Environ. Health Perspect. 112(12) 1217-24.

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RASS 2005 AwardBest manuscript demonstrating
application of risk assessment
Awards Committee

• Kannan Krishnan, Univ. Montreal (Chair)
• Steve DiZio, Cal EPA
• Lynne Haber, TERA
• Deborah Proctor, Exponent
• Resha Putzrath, EPA Forum
• Ed Sargent, Merck

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2005 RASS Top Ten Papers APPLICATION OF RISK
ASSESSMENT

• 1. Babich MA, Chen SB, Greene MA, Kiss CT, Porter
  WK, Smith TP, Wind ML, Zamula WW. (2004). Risk
  assessment of oral exposure to diisononyl
  phthalate from childrens products. Regul.
  Toxicol. Pharmacol. 40(2) 151-67.
• 2. Booze TF, Reinhardt TE, Quiring SJ and Ottmar
  RD. (2004). A screening level assessment of the
  health risks of chronic smoke exposure for
  wildland firefighters. Journal of Occupational
  and Environmental Hygiene 1 296-305.
• 3. Conolly RB, Kimbell JS, Janszen D, Schlosser
  PM, Kalisak D, Preston J and Miller FJ. (2004).
  Human respiratory tract cancer risks of inhaled
  formaldehyde dose response predictions from
  biologically-motivated computational modeling of
  as combined rodent and human dataset.
  Toxicological Sciences 82 279-296.
• 4. Farrrow S. (2004). Using risk assessment,
  benefit-cost analysis, and real options to
  implement a precautionary principle. Risk Anal.
  24(3) 727-35.
• 5. Himmelstein MW, Carpenter SC, Evans MV,
  Hinderliter PM, Kenyon EM. (2004). Kinetic
  modeling of beta-chloroprene metabolism II. The
  application of physiologically based modeling for
  cancer dose response analysis. Toxicol. Sci.
  79(1) 28-37.

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2005 RASS Top Ten Papers APPLICATION OF RISK
ASSESSMENT

• 6. Kirman CR,, Sweeney LM, Teta MJ, Sielken RL,
  Valdez-Flores C, Albertini RJ and Gargas ML.
  (2004). Addressing nonlinearity in the
  exposure-response relationship for a genotoxic
  carcinogen cancer potency estimates for ethylene
  oxide. Risk Analysis 24 1165.
• 7. Renwick AG. (2004). Establishing the upper end
  of the range of adequate and safe intakes for
  amino acids a toxicologists viewpoint. J.
  Nutr. 134(6 Suppl) 1617S-1624S.
• 8. Schoen A, Beck B, Sharma R and Dubé E. (2004)
  Arsenic toxicity at low doses epidemiological
  and model of action considerations. Toxicology
  and Applied Pharmacology 198 253-267.
• 9. Sweeney LM, Andersen ME and Gargas ML. (2004).
  Ethyl acrylate risk assessment with a hybrid
  computational fluid dynamics and
  physiologically-based nasal dosimetry model.
  Toxicological Sciences 79 394-403.
• 10. Tsuji JS, Benson Rj, Schoof RA, Hook GC.
  (2004). Health effect levels for risk assessment
  of childhood exposure to arsenic. Regul.
  Toxicol. Pharmacol. 39(2) 99-110.

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Risk Assessment Specialty Section 2005

• Best Paper Demonstrating the
• Application of
• Risk Assessment
• Kirman CR,, Sweeney LM, Teta MJ, Sielken RL,
  Valdez-Flores C, Albertini RJ and Gargas ML.
  (2004). Addressing nonlinearity in the
  exposure-response relationship for a genotoxic
  carcinogen cancer potency estimates for ethylene
  oxide. Risk Analysis 24 1165.

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RASS Web Page Update

• RASS Description, Goals and Activities
• Links
• Monthly Telecons
• Dates and Downloads
• History of RASS
• Current and Previous Officers and all Presidents
• Annual Meeting
• Best Abstract Awards
• Best Student Abstracts
• RASS Endorsed Symposia, etc.

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RASS Web Page Update (continued)

• Links
• Annual Meeting
• Information regarding reception
• Information regarding Panel Discussion Tonight
• Best Manuscript Awards from 2004 and 2005
• Upcoming Events
• CCT on Probabilistic Risk Assessment
• Links to other sites and meetings of interest

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Just Getting Started
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Seeking Your Input

• Logo Contest
• History of RASS
• Feedback on
• Web Page
• Pictures
• Graphics
• Send to DProctor_at_Exponent.com

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Logo Contest
First Entry
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Logo Contest
Second Entry
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Logo Contest
Third Entry
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Logo Contest

• Extended for 1 week after SOT (3/17/05)
• Email Your Entries to Deb Proctor
  (Dproctor_at_Exponent.com)
• Computer and drawing skills are not required
• Prepares will be Anonymous
• RASS Membership will vote by email
• Winner by End of March

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Proof that Ability to Draw is Not a Requirement
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RASS 2005/06 Program Activities

• Submission of symposia and continuing education
  proposals
• Need your input ideas
• Evaluate venue attributes that best suit topic
• Symposium
• Workshop
• Continuing Education
• Provide endorsements
• Four primary endorsements
• Help fully develop proposals
• Follow-up Contemporary Concepts in Toxicology
  (CCT) program
• PRA proposal
• Program development and funding formula

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RASS 2005/06 Program Activities (cont.)

• Post-doc and graduate student memberships in RASS
• Risk assessment programs
• Institutional contacts
• Enrolment
• RASS Newsletter
• Bi-monthly, electronic
• Update on activities, hot issues, announcements,
  opportunities,
• Membership participation
• Teleconference presentations
• Risk assessment tools
• Topics TBD by YOU please let us know!

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RASS 2005 ReceptionConclusion

• Open Forum
• Panel Discussion Dose-dependent transitions in
  mechanisms of toxicity
• William Slikker, US FDA NCTR
• Ray David, Eastman Kodak
• Rory Conolly, CIIT Centers for Health Research
• Dale Hattis, Clark University
• William Farland, US EPA ORD
• David Jacobson-Kram, US FDA CDER