NEUROMUSKULARNA VEZA

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NEUROMUSKULARNA VEZA
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NEUROMUSKULARNA VEZA ( funkcionalna veza
nervne i miicne celije)
Globalni izgled neuromuskulane veze 1. Akson2.
Zavrna motorna ploca3. Miicno vlakno4.
Miofibrile
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NEUROMUSKULARNA VEZA
Detaljni izgled neuromuskulane veze 1.
Presinapticki terminalni zavretal2.
Sarkolema3. Sinapticka vezikula4. Nikotinski
receptor za acetil-holin 5. Mitohondrije
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NEUROMUSKULARNA VEZA ( funkcionalna veza
nervne i miicne celije)
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NEUROMUSCULAR JUNCTION. Electro micrograph
showing a cross section through the neuromuscular
junction. T is the axon terminal, M is the muscle
fiber. The arrow shows junctional folds with
basal lamina. Postsynaptic densities are visible
on the tips between the folds. Scale is 0.3 µm
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NEUROMUSKULARNA VEZA ( funkcionalna veza
nervne i miicne celije)
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NEUROMUSKULARNA VEZA
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NEUROMUSKULARNA VEZA
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NEUROMUSKULARNA VEZA ( funkcionalnI spoj
izmedju nervne i miicne celije)


Strychnos toxifera Chondrodendron tomentosum
Kurare D-tubokurarin
Claude Bernard
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NEUROMUSKULARNA VEZA
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MEMBRANE-ASSOCIATED PROTEIN COMPLEXES INSKELETAL
MUSCLE FIBERS CONNECTIVE TISSUE
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MEMBRANE-ASSOCIATED PROTEIN COMPLEXES INSKELETAL
MUSCLE FIBERS CONNECTIVE TISSUE
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NEUROMUSKULARNA VEZA
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Sites of action by major classes of animal venom
neurotoxins.
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The figure shows synaptic pathology occurring at
neuromuscular junctions in the transversus
abdominis muscle from a mouse model of Spinal
Muscular Atrophy (SMA). This confocal micrograph
shows examples of a fully-occupied endplate, a
partially-occupied endplate and a vacant
(denervated) endplate
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NEUROTRANSMITERI
Definisanje neke supstance kao neurotransmitera
podrazumeva da ona poseduje sledece
karakteristike A) Sintetie se u neuronu
prisutna je u presinaptickim zavretcima i
oslobadja se u kolicini dovoljnoj da izazove
efekat na postsinapticku celiju. B) Kada se
primeni egzogeno u odredjenoj koncentraciji,
izaziva istovetno dejstvo kao i endogeni
neturotransmiter. C) U nivou sinapse postoji
specifican mehanizam koji uklanja
neurotransmiter. D) Neurotransmiter ima
neravnomernu distribuciju u okviru nervnog
sistema, a taj raspored prati odgovarajuca
distribucija specificnih receptora i enzima
koji ucestvuju u njegovom metabolizmu.
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NEUROTRANSMITERI
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NEUROTRANSMITERI
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NEUROTRANSMITERI
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NEUROTRANSMITERI
Sir Bernard Katz Shared the Nobel Prize in
physiology or medicine in 1970 for his discovery
that neurotransmitter release at synapses is
"quantal"--that is, that at any particular
synapse the amount of neurotransmitter released
is never less than a certain amount, and if more
is always an integral number times this amount.
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Model of ionotropic synaptic transmission. A
transmitter substance binds to a receptor and
opens a channel, changing membrane conductance
and, therefore, membrane potential.
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Models of metabotropic synaptic transmission.
Here the second messenger is shown as cAMP, but
cGMP or another substance or even several
different substances could serve as well.
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ACETIL HOLIN
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Acetylcholine receptor blocked by cobra venom. A
similar effect can be achieved by high doses of
curare or nicotine
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DOPAMIN
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NIKOTINSKI ACh RECEPTOR
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NIKOTINSKI ACh RECEPTOR
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NIKOTINSKI ACh RECEPTOR
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KAINATNI RECEPTOR
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RECEPTORI VEZANI ZA G PROTEINE
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MUSKARINSKI RECEPTOR primer aktivacije receptora
vezanog za G proteine
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MUSKARINSKI RECEPTOR 1
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MUSKARINSKI RECEPTOR 2
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MUSKARINSKI RECEPTOR 3
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MUSKARINSKI RECEPTOR 4