ANABOLIC STEROIDS

1
ANABOLIC STEROIDS

• Lew Spirtos
• YSU Chemistry 3790, November 30th, 2005

http//www.pharma-tek.com/Images2004/PRODUCTSEllip
seSyringePS185mjpg.jpg
2
HISTORY Natural Era

• 1930s- dogs
• 1940s- POWs
• 1950s- athletes
• 1964- turning point

http//www.freakingnews.com/entries/10500/10853TYb
x_w.jpg
3
HISTORY Synthetic Era

• 1960s
• world class athletes
• 1970
• 15 college athletes ( )
• 1980s
• black market
• 1990
• controlled dangerous substances
• FDA DEA
• Current
• Estimated 1 million steroid users ( )
• 90 users male ( )
• sports

http//www.anabolicsmall.com/roida3a.htm
http//www.pppdesign.net/otw/drugawareness/steroid
s.htm
http//www.pppdesign.net/otw/drugawareness/steroid
s.htm
4
What is an anabolic steroid?

• Natural Bioactive Molecules
• promote cell division/ growth
• Testosterone
• Estrogen
• Cholesterol

• http//en.wikipedia.org/wiki/Testosterone

http//en.wikipedia.org/wiki/Cholesterol
5
What is a synthetic anabolic?

• Structural Definition
• Not found in nature.
• How they are prepared.
• Semi-synthetic
• Natural Source Materials
• Synthetic Chemistry Derivation
• Advantages
• Cost
• Highly variable structure

6
USES

• Stimulation of
• Sexual development
• Growth
• Puberty
• Bone marrow
• Appetite
• Muscle Mass
• Stamina

http//perso.wanadoo.fr/topmuscu/images/ronnie20f
ace203.jpg
7
Taking Anabolic steroids

• Oral
• Injection
• Sanitation
• Intramuscular injection
• Avoidance
• Nerves
• Blood vessels
• Sites
• Deltoid in upper arm
• Outer thigh
• Buttocks

http//www.steroid.com/inject.php
8
SYNTHESIS
http//www.amazonherbsforanimals.com/images/feedin
ghorseherbs.jpg

• http//www.project-aware.org/images/Image23.gif

9
Synthesis
http//intmedweb.wfubmc.edu/grand_rounds/2001/adre
nalincid_files/image002.jpg
http//www.uiowa.edu/c099001/sex/steroids20gifs/
endo_intracrine2.gif
10
BALCO LAB

• Production/manufacture
• Victor Conte
• MLB Team Balco

http//wwwimage.cbsnews.com/images/2004/06/16/imag
e623473x.jpg
http//images.google.com/images?qbondssteroidss
vnum10hlenlrieUTF-8start20saN
http//latinobaseball.com/head68.jpg
11
Legal and Moral Issues

• Is it cheating?
• Is it legal?
• Is it worth it?

http//www.canaljoven.com/imagenes/deporte/montgom
ery/montgomery.jpg
12
Detection Times

• Nandrolone decanoate- 18 mos.
• Depo-testosterone- 3 mos.
• Parabolan- 5 weeks
• Andriol- 1 week
• Clenbuterol- 4 days

http//cache.boston.com/images/bostondirtdogs//Hea
dline_Archives/steroid.jpg
http//www.anabolex.com/?c130a1052
13
Detection Methods

• Separate from blood plasma.
• Preseparation
• Gas Chromatography (GC) Liquid Chromatography
  (HPLC)
• Idendify them
• Mass Spectroscopy
• Race between forensic scientists users
  regulators

14
Test Standards and Accuracy

• Procedures
• EMIT- workplace
• RIA- government
• Courier- Olympic athletes
• False positives
• Ibuprofen
• Cold remedies
• Antibiotics
• True positives
• Poppy seeds
• Testosterone supplements

http//www.medschool.lsuhsc.edu/microbiology/DMIP/
EmitR.gif
15
Not So Fast

• Tests used to detect counter measures (urine
  tampering)
• Urine color
• Urine temperature
• Creatinine
• pH
• Specific gravity

http//www.cbc.ca/news/background/steroids/gfx/tit
lephoto.jpg
16
Side Effects

• Skin conditions (presumptive test)
• Liver
• Male reproductive
• Cardiovascular
• Psychological

http//www.testosteronesteroids.com/images/steroid
s.jpg
17
ROID RAGE

• Altered hormone levels
• Inability to control behavior
• Severe mood swings
• Irritability
• Violent aggression
• Depression

http//espn.go.com/media/nfl/2002/1211/photo/s_rom
anowski_fp.jpg
http//www.calpoly.edu/rkiley/roidrage.jpg
18
ANDRIOL

• Dosage- 8-16 40 mg caps daily
• Street price- 1 for 40 mg
• Liver bypass lymphatic absorption
• Orally available testosterone
• Half-life 3-5 hrs
• Compatibility

http//www.bodybuilding.com/fun/catandriol.htm
http//www.bodybuilding.com/fun/catandriol.htm
http//www.steroidtips.com/andriol.jpg
19
DANATROL

• Dose- 200-400 mg daily
• 2-3 per 200 mg cap
• Lack of popularity
• Slightly androgenic
• Expensive
• Anti-aromatase prevents testosterone side
  effects
• Bloating
• Increased body fat
• Gyno

http//www.bodybuilding.com/fun/catdanatrol.htm
http//www.bodybuilding.com/fun/catdanatrol.htm
20
Methyltestosterone

• Dosage 25-50 mg/ day
• Price 2 50 mg tablets for 1
• First oral steroid
• Works well bad side effects and high cost
• Potent androgen
• Prone to roid rage
• High tendency to aromatize
• Severe bloat and water retention

http//www.bodybuilding.com/fun/catmethyl.htm
http//www.bodybuilding.com/fun/catmethyl.htm
21
Orabolin

• Dosage 20-50 mg/ day
• Price 1-2 for 20 mg
• Good androgen binding
• Lack of 19th C
• Reesterify easily
• Good progesterone binding
• Worsens estrogenic side effects

http//www.bodybuilding.com/fun/catorabolin.htm
http//www.bodybuilding.com/fun/catorabolin.htm
22
SUSTANON 250

• Dosage 250-1000 mg/ week
• Price 10-30/ ml
• 4 esters increase exposure to adipose tissue
• Stacks well with any compound
• Extreme anabolic tendencies
• Good and bad
• Injectables

http//www.bodybuilding.com/fun/catsust.htm
http//www.bbc.co.uk/radio1/onelife/health/drugs/i
mages/steroids_hit.jpg
23
References

• www.steroid.com
• www.bodybuilding.com
• www.steroidworld.com
• www.wikipedia.com
• www.wrestlingusa.com
• www.anabolicsmall.com
• www.steroids.com
• www.pharmaeurope.com