CIDER

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CIDER

• Clinical Investigation Data Exploration Repository

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CIDER

• Clinical Investigation Data Exploration
  Repository
• Joint venture of BJC WUSM
• Data repository to contain routine patient care
  (inpatient and outpatient) data
• Advanced Query functionality through web
  interface
• Restricted data access / Role Management
• Data Interface to external systems like CSMS
• Controlled Vocabulary support

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Need for CIDER

• Clinical Translational research goals
• Rapidly convert novel advances in basic science
  to Patient care
• Get quick feedback on customized diagnostics and
  therapeutics for further refinements back to the
  bench
• Need to analyze complex biomedical data
• Clinical Information
• Routine laboratory tests, imaging, biospecimens
• Molecular profiling and genome annotation

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Need for CIDER contd

• Data sets must be co-analyzed visualized to
  gain a comprehensive understanding of underlying
  processes occurring in multi-factorial diseases
• Easy access to this data for physicians,
  clinician-scientists, and bench scientists
• Reduce barrier between basic science and clinical
  research

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Current challenges

• No easy way to access consolidated patient data
• Privacy and confidentiality risks
• No seamless and regulated data access
• HIPAA regulations

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How CIDER addresses the challenges

• No easy way to access consolidated patient data -
  Consolidated repository
• Privacy and confidentiality risks - Secured
  data access based on user role and project
  privileges
• No seamless and regulated data access -
• Seamless regulated data access
• HIPAA regulations - HIPAA training a must for all
  CIDER users

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Solution CIDER
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CIDER Data Repository

• Discrete Data from ClinDesk (IP Data)
• Demographics
• Encounters
• Labs
• Medications
• Vitals
• Allergies
• Microbiology
• Documents from ClinDesk, including Scanned
  Documents
• (Hospital-based IP OP Data)
• NLP (Natural Language Processing)
• AllScripts Data (WU Physician Offices OP Data)
• NextGen Data (BJC Medical Group Physician
  Offices OP Data)
• Diagnostic Images
• Other Sources (e.g.. MDL Discrete data)

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CIDER Overall Timeline
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Release-1 Modules

• Manage Users / Manage Projects
• Query Module
• Vocabulary Interface
• Audit System
• Data Delivery (conversion and interface)
• Dashboard
• APIs to external systems like CSMS

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references
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CIDERData flow
CDR
Data Repository
AllScripts
NextGen
CIDER
Imaging
Research World
Health Care World
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CIDER-DATA TO CIDER-DOMAIN-MODEL
Via ETL Process
CIDER Database (DB2)
Data Source
DB2 XML Database
XSD - XML Schema Definition
XSDs
Object Model Graphical Representation of Data
Elements and their Relationships
OBJECT MODEL
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Via ETL Process
CIDER Database (DB2)
Data Source
DB2 XML Database
XSD - XML Schema Definition
XSDs
i-Query
Object Model Graphical Representation of Data
Elements and their Relationships
Generate Metadata
X-Query
OBJECT MODEL
What data to query?
Categories
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CIDER Query Module
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CIDER Workflow
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CIDER Technology

• Web based GUI (Graphical User Interface) which
  uses Java, Ajax, Flex and Web services
  technologies
• Hierarchical and real-time data in XML
• Federated DB2 Databases on Linux
• Advanced Query capabilities (Graphical) using
  XQuery / SQL-XML
• Multiple vocabulary support (SNOMED CT, LOINC
  etc)

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CIDER Architecture contd