Bipolar Depression: Quetiapine Effective in a Broad Range of Symptoms

1
Bipolar Depression Quetiapine Effective in a
Broad Range of Symptoms

Apparent sadness


Reported sadness


Inner tension



Reduced sleep
Reduced appetite

Quetiapine 600 mg (n 170)
Concentration difficulties

Quetiapine 300 mg (n 172)

Lassitude
Placebo (n 169)

P lt 0.001 P lt 0.01 (vs placebo)
Inability to feel


Pessimistic thoughts



Suicidal thoughts
0
10
20
30
40
50
60
70
80
ITT, LOCF
Mean Percent Change in MADRS Item Score
Calabrese JR, et al. Am J Psychiatry.
20051621351-1360.