Neuroimaging Schizophrenia and Related Disorders

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• Neuroimaging Schizophrenia and Related Disorders
• Clinical Neuroscience Division
  
  
• Laboratory of Neuroscience
  
  
• Department of Psychiatry, and
  Surgical Planning Laboratory,
  MRI Division, Department of Radiology
  Brigham Womens Hospital,
  Harvard Medical School
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Volumes
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Coronal SPGR Image of Normal and SZ
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Caudate Nucleus ROI
B
C
A
D
E
F
(Koo et al., In Preparation)
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Caudate Nucleus
(Koo et al., In Preparation)
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Shape
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Shape Analysis of Caudate Nucleus
Regions of inflation (blue color) and deflation
(red color) in SZ with pgt0.05
(Levitt et al., in Preparation)
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DTI and Other Complex Data

• How to Quantify?
• How to integrate with other measures?

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Axonal Fibers using Diffusion Tensor Imaging of
3T MRI
Hae-Jeong Park, Ph.D.
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Manual Delineation of Fiber Tracts
Yellow Cortico-Spinal Tract Blue Corpus
Callosum Red Cingulate Fasciculus Green
Arcuate Fasciculus Orange Uncinate Fasciculus
(Mamata et al., AJNR 2002)
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Fiber Tractography Based onSpectral Graph
Analyses
Sagittal and axial view of the white matter fiber
tracts, which demonstrate anatomical connectivity
by fibers of similar colors.
Laplacian Eigenmaps
(Brun et al., In Preparation)
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Anterior Limb of the Internal Capsule ROI was
drawn on 6 consecutive slices. The first 3
include the anterior limb of the internal capsule
(left-purple and right-green), and the next three
include the posterior limb of the internal
capsule (left-blue and right-yellow).
Problems How to measure the whole bundle that
goes through the ROI? How to better separate
anterior and posterior limbs of the internal
capsule?
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Conclusions

• How can we automatically measure brain structures
  with robustness and precision?
• How can we quantify white matter fiber tracts?
• How can we associate multiple medical images with
  non-imaging data?