Experience with Amphiphilic Gel Network Emulsifier Chemistry

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Experience with Amphiphilic Gel Network
Emulsifier Chemistry

• Arthur C.W.Georgalas
• TRI-K Industries, Inc. Northvale, N.J., U.S.A.

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Amphiphile Phase Diagram
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Liquid Crystalline Gel Network Stabilization
Mechanism
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Lamellar Gel Network in Emulsion
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Formulation of Gel Network by Viscosity
Measurements
optimum ratio
Viscosity
4 / 6
3 / 7
5 / 5
2 / 8
1 / 9
6 / 4
Ratio hydrophilic emulsifiers / Co-emulsifiers
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Adjustment of Gel Network in the Presence of
Electrolytes
optimum ratio with electrolytes
optimum ratio without electrolytes
Viscosity
4 / 6
7 / 3
3 / 7
5 / 5
2 / 8
1 / 9
6 / 4
Ratio Hydrophilic emulsifiers / Co-emulsifiers
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Impact of Various Parameters on Gel Network
Composition
Concentration of hydrophilic emulsifier in the
total mixed emulsifier system
Electrolyte concentration
Energy during manufacturing
Polyol Ethanol content
Micropigment concentration
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Emulsion Viscosity vs. Concentration
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Emulsion viscosity vs.Concentration
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TEWL Barrier Function Return
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Reduction of Erythema by Creams after SDS
Treatment
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Gel Network Emulsion Water Resistance

• Sunscreen formulation organic inorganic
  actives
• In Vitro water resistance testing 69 efficacy
  retention

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Amphiphilic Gel Network Emulsifier Formulation

• Preformulation of emulsifier blend results in
  optimal performance
• Viscosity/ stability maximized
• Skin Compatibility optimized
• Functional Properties- moisture retention water
  resistance- improved